Evidence map›Paper›PMID 30621454›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2019

Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery.

Amy Mantz, Angela K Pannier

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Nucleic Acid Delivery from Granular Hydrogels.Advanced healthcare materials · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy MantzDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Angela K PannierDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
University of Nebraska–Lincoln · US

Funding

Using Cell Priming and Telecommunications Modeling to Enhance Gene Delivery for Stem Cell TherapiesDP2EB025760 · NIBIB · UNIVERSITY OF NEBRASKA LINCOLN · PI PANNIER, ANGELA K · 2017 to 2022
$2.8M
NIBIB NIH HHS DP2 EB025760
6 · The paper itself

Abstract

impact statementThis review summarizes how biomaterial substrate modifications (e.g. chemical modifications like natural coatings, ligands, or functional side groups, and/or physical modifications such as topography or stiffness) can prime the cellular response to nonviral gene delivery (e.g. affecting integrin binding and focal adhesion formation, cytoskeletal remodeling, endocytic mechanisms, and intracellular trafficking), to aid in improving gene delivery for applications where a cell-material interface might exist (e.g. tissue engineering scaffolds, medical implants and devices, sensors and diagnostics, wound dressings).

Indexed as

Gene Transfer TechniquesBiocompatible MaterialsBiotechnologyExtracellular MatrixFocal AdhesionsTransfectionBiocompatible MaterialsBiomaterialsbiotechnologyextracellular matrixgene deliveryprimingtransfection

Identifiers

PMID30621454
PMCPMC6405826
OpenAlexW2911210836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.