Evidence map›Paper›PMID 30621357›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds.

Ahmet Çağrı Karaburun, Betül Kaya Çavuşoğlu, Ulviye Acar Çevik, Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Özlem Atlı, Ali Savaş Koparal, Zafer Asım Kaplancıklı

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Benzimidazole derivatives as potentFuture medicinal chemistry · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Development in medicinal chemistryPharmaceutical patent analyst · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ahmet Çağrı KaraburunDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. ackarabu@anadolu.edu.tr.
Betül Kaya ÇavuşoğluDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. betulkaya@anadolu.edu.tr.
Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. uacar@anadolu.edu.tr.
Derya OsmaniyeDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. dosmaniye@anadolu.edu.tr.
Begüm Nurpelin SağlıkDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. bnsaglik@anadolu.edu.tr.
Serkan LeventDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. serkanlevent@anadolu.edu.tr.ORCID 0000-0003-3692-163X
Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. yozkay@anadolu.edu.tr.ORCID 0000-0001-8815-153X
Özlem AtlıDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. oatli@anadolu.edu.tr.
Ali Savaş KoparalOpen Education Faculty, Anadolu University, Eskişehir 26470, Turkey. askopara@anadolu.edu.tr.
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey. zakaplan@anadolu.edu.tr.ORCID 0000-0003-2252-0923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this hypothesis, in this paper, a series of benzimidazole-oxadiazole compounds were synthesized and subjected to antifungal activity evaluation. In vitro activity assays indicated that some of the compounds exhibited moderate to potent antifungal activities against tested

Indexed as

Amphotericin BAnimalsAntifungal AgentsBenzimidazolesCandida albicansCell SurvivalDrug DesignKetoconazoleMiceMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureNIH 3T3 CellsOxadiazolesProtein BindingStructure-Activity Relationship1,3,4-oxadiazoleAmphotericin BAntifungal AgentsBenzimidazolesKetoconazoleOxadiazoles1,3,4-oxadiazoleantifungal activitybenzimidazolecytotoxicityergosterol biosynthesismolecular docking

Identifiers

PMID30621357
PMCPMC6337182

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.