Evidence map›Paper›PMID 30621339›Full record

ReviewInternational journal of molecular sciences2019

Bacteriocins and Bacteriophages: Therapeutic Weapons for Gastrointestinal Diseases?

Loris Riccardo Lopetuso, Maria Ernestina Giorgio, Angela Saviano, Franco Scaldaferri, Antonio Gasbarrini, Giovanni Cammarota

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 104 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Does Phage Therapy Need a Pan-Phage?Pathogens (Basel, Switzerland) · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Antimicrobial Potential of the GeneraAntibiotics (Basel, Switzerland) · 2022
    Review
  14. Bacteriocins: Properties and potential use as antimicrobials.Journal of clinical laboratory analysis · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Antibiotics (Basel, Switzerland) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Loris Riccardo LopetusoIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. lopetusoloris@libero.it.ORCID 0000-0002-5747-2055
Maria Ernestina GiorgioIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. estin.gio3@gmail.com.
Angela SavianoIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. saviange@libero.it.
Franco ScaldaferriIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. francoscaldaferri@gmail.com.ORCID 0000-0001-8334-7541
Antonio GasbarriniIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. antonio.gasbarrini@unicatt.it.
Giovanni CammarotaIstituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy. giovanni.cammarota@unicatt.it.
Università Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriocins are bactericidal peptides, ribosomally synthesized, with an inhibitory activity against diverse groups of undesirable microorganisms. Bacteriocins are produced by both gram-positive and gram-negative bacteria, and to a lesser extent by some archaea. Bacteriophages are viruses that are able to infect bacterial cells and force them to produce viral components, using a lytic or lysogenic cycle. They constitute a large community in the human gut called the phageome, the most abundant part of the gut virome. Bacteriocins and bacteriophages may have an influence on both human health and diseases, thanks to their ability to modulate the gut microbiota and regulate the competitive relationship among the different microorganisms, strains and cells living in the human intestine. In this review, we explore the role of bacteriocins and bacteriophages in the most frequent gastrointestinal diseases by dissecting their interaction with the complex environment of the human gut, analyzing a possible link with extra-intestinal diseases, and speculating on their possible therapeutic application with the end goal of promoting gut health.

Indexed as

AnimalsBacterial InfectionsBacteriocinsBacteriophagesGastrointestinal DiseasesGastrointestinal TractHumansInflammationBacteriocinsantibioticsbacteriocinsbacteriophagesdysbiosisgastrointestinal diseasesgut barriergut microbiotavirus

Identifiers

PMID30621339
PMCPMC6337595
OpenAlexW2908503886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.