Evidence map›Paper›PMID 30621322›Full record

ArticleMolecules (Basel, Switzerland)2019

A Novel Series of Acylhydrazones as Potential Anti-

Anca-Maria Borcea, Gabriel Marc, Ioana Ionuț, Dan C Vodnar, Laurian Vlase, Felicia Gligor, Andreea Pricopie, Adrian Pîrnău, Brîndușa Tiperciuc, Ovidiu Oniga

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Anca-Maria BorceaDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. borcea.anca@umfcluj.ro.
Gabriel MarcDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. marc.gabriel@umfcluj.ro.ORCID 0000-0001-9397-0388
Ioana IonuțDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. ionut.ioana@umfcluj.ro.
Dan C VodnarDepartment of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăştur Street, 400372 Cluj-Napoca, Romania. dan.vodnar@usamvcluj.ro.
Laurian VlaseDepartment of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. laurian.vlase@umfcluj.ro.ORCID 0000-0002-0664-3387
Felicia GligorPreclinic Department, Pharmacy Specialization, Faculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Street, 550169 Sibiu, Romania. felicia.gligor@ulbsibiu.ro.
Andreea PricopieDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. pricopie.andreea@umfcluj.ro.
Adrian PîrnăuNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, 400293 Cluj-Napoca, Romania. adrian.pirnau@itim-cj.ro.
Brîndușa TiperciucDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. brandu32@yahoo.com.ORCID 0000-0002-1333-5649
Ovidiu OnigaDepartment of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 Victor Babeş Street, 400012 Cluj-Napoca, Romania. onigao65@yahoo.com.
Iuliu Hațieganu University of Medicine and Pharmacy · ROLucian Blaga University of Sibiu · RONational Institute for Research and Development of Isotopic and Molecular Technologies · ROUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · RO

Funding

"Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania doctoral research project number 7690/11/2016, 5200/10/2017 and 3067/3/2018
6 · The paper itself

Abstract

In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles. A novel series of acylhydrazones bearing a 1,4-phenylene-bisthiazole scaffold was designed based on an analysis of structures known to possess anti-

Indexed as

Antifungal AgentsCandidaDrug DesignFluconazoleHydrazonesMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureProtein BindingStructure-Activity RelationshipAntifungal AgentsFluconazoleHydrazonesacylhydrazoneADMETanti-Candidalanosterol 14α-demethylasemolecular modelingthiazole

Identifiers

PMID30621322
PMCPMC6337626
OpenAlexW2908476598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.