ReviewNutrients2019
Dietary Factors Associated with Frailty in Old Adults: A Review of Nutritional Interventions to Prevent Frailty Development.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Association of frailty and pre-frailty with cardiovascular mortality: a meta-analysis of 26 cohort studies.Frontiers in public health · 2025Pooled it
- Trial
- Contribution of Nova-classified ultraprocessed foods to energy and nutrient intakes in very old people: the Newcastle 85+ Study.BMJ open · 2026Observational
- Association between Japanese balanced diet and frailty: the modifying effects of social connections in Japanese older adults.BMC geriatrics · 2026Article
- Effectiveness of Nutritional Interventions in Pre-Frail or Frail Older Adults: A Scoping Review.Journal of clinical medicine · 2026Review
- Article
- Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study.BMC medicine · 2025Article
- Article
- Sugar and sugar-sweetened beverages in relation to premature aging in adult survivors of childhood cancer.British journal of cancer · 2024Article
- Association between healthy lifestyle and frailty in adults and mediating role of weight-adjusted waist index: results from NHANES.BMC geriatrics · 2024Article
- Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study.Nutrition journal · 2024Article
- What is the additive value of nutritional deficiency to VA-FI in the risk assessment for heart failure patients?The journal of nutrition, health & aging · 2024Article
- Regional differences in protein intake and protein sources of Korean older adults and their association with metabolic syndrome using the 2016-2019 Korea National Health and Nutrition Examination Surveys: a cross-sectional study.Korean journal of community nutrition · 2024Article
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- The relationship between dietary intake of ω-3 and ω-6 fatty acids and frailty risk in middle-aged and elderly individuals: a cross-sectional study from NHANES.Frontiers in nutrition · 2024Article
- Vitamin K insufficiency predicts incidence of frailty in community-dwelling older adults: The Otassha Study.Journal of bone and mineral metabolism · 2023Article
- Fish intake and pre-frailty in Norwegian older adults - a prospective cohort study: the Tromsø Study 1994-2016.BMC geriatrics · 2023Article
- Dairy Food Intake Is Not Associated With Frailty in Adults From the Framingham Heart Study.Journal of the Academy of Nutrition and Dietetics · 2023Article
- Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers.Frontiers in sports and active living · 2023Article
- Loss of Muscle Mass and Vulnerability in Institutionalized Older Adults.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty syndrome is a medical condition that is characterised by a functional decline, usually from 65 years old on, and creates the need for assistance to perform daily living activities. As the population ages, the need for specialised geriatric care will increase immensely, and consequently, the need for specialised services for the care of these people will increase accordingly. From a nutritional point of view, to control or balance the nutritional status of residents will be essential in order to prevent sarcopenia and, consequently, frailty development. In this line, previous studies have highlighted the association among low energy intake, inadequate intake of protein and vitamin D, and an increased risk of frailty development. However, there is a lack of intervention studies on frail patients, especially in the realm of quality clinical trials. The few studies performed to date seem to indicate that there is a protective role of protein supplementation against frailty syndrome. In this regard, it is tempting to suggest daily 30 g protein supplements to prevent frailty. However, it is well established that excess protein can also be harmful; therefore, specific individual characteristics should be considered before prescribing these supplements. On the other hand, the relevance of other nutritional interventions, such as vitamin D, omega-3, and medium-chain triglycerides, is much more scarce in the literature. Therefore, we encourage the development of new clinical trials to carry out effective therapies to prevent frailty development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.