Evidence map›Paper›PMID 30621310›Full record

ArticleMolecules (Basel, Switzerland)2019

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing.

Anna M D Végh, A Dénise den Haan, Lucía Cócera Ortega, Arie O Verkerk, Joost P G Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A B van Veen, Mischa Klerk, Jurgen Seppen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Anna M D VéghHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. a.m.d.vegh@lumc.nl.
A Dénise den HaanHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. denisedenhaan@gmail.com.
Lucía Cócera OrtegaHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. l.coceraortega@amc.uva.nl.
Arie O VerkerkHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. a.o.verkerk@amc.uva.nl.ORCID 0000-0003-2140-834X
Joost P G SluijterDepartment of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. jsluijter@umcutrecht.nl.
Diane BakkerHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. diane.bakker@amc.uva.nl.
Shirley van AmersfoorthHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. s.c.vanamersfoorth@amc.uva.nl.
Toon A B van VeenMedical Physiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. a.a.b.vanveen@umcutrecht.nl.
Mischa KlerkHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. m.klerk@amc.uva.nl.
Jurgen SeppenTytgat Institute, Academic Medical Center, 1105 BK Amsterdam, The Netherlands. j.seppen@amc.uva.nl.
Jacques M T de BakkerHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. j.m.debakker@amc.uva.nl.
Vincent M ChristoffelsDepartment of Medical Biology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. v.m.christoffels@amc.uva.nl.
Dirk GeertsHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. h.a.geerts@amc.uva.nl.ORCID 0000-0002-6386-8187
Marie José T H GoumansCell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. M.J.T.H.Goumans@lumc.nl.
Hanno L TanHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. h.l.tan@amc.uva.nl.
Gerard J J BoinkHeart Center, Clinical & Experimental Cardiology, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. g.j.boink@amc.uva.nl.
Amsterdam UMC Location University of Amsterdam · NLLeiden University Medical Center · NLUniversity Medical Center Utrecht · NL

Funding

European Research Council 714866Hartstichting 2014T065Rembrandt Institute for Cardiovascular Research 2013ZonMw 016.156.162
6 · The paper itself

Abstract

Sustained pacemaker function is a challenge in biological pacemaker engineering. Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation. We studied whether lentivirally transduced CMPCs that express the pacemaker current

Indexed as

Gene Transfer TechniquesAnimalsGenetic TherapyGreen Fluorescent ProteinsHeart VentriclesHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsMyocytes, CardiacPatch-Clamp TechniquesPotassium ChannelsRatsStem CellsStem Cell TransplantationGreen Fluorescent ProteinsHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsPotassium Channelscell therapygene therapyHCN channelspacemakersprogenitor cells

Identifiers

PMID30621310
PMCPMC6337610
OpenAlexW2908394255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.