Evidence map›Paper›PMID 30621280›Full record

ReviewToxins2019

Yasmin Leshem, Ira Pastan

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. The Role of Antibody-Based Therapies in Neuro-Oncology.Antibodies (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Yasmin LeshemLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. jasminleshem@gmail.com.
Ira PastanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. pastani@mail.nih.gov.ORCID 0000-0002-9223-0270
National Institutes of Health · US

Funding

Immunotoxin Therapy of Solid and Hematopoietic Tumors: Preclinical StudiesZIABC008753 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PASTAN, IRA · 2009 to 2024
$33.1M
IMMUNOTOXIN THERAPY OF SOLID AND HEMATOPOIETIC TUMORS: PRECLINICAL STUDIESZ01BC008753 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PASTAN, IRA · 1996 to 2008
$3.2M
NCI NIH HHS Z01 BC008753
6 · The paper itself

Abstract

Immunotoxins are protein drugs composed of a targeting domain genetically fused to a protein toxin. One killing domain being explored is a truncated

Indexed as

PseudomonasAnimalsCTLA-4 AntigenExotoxinsGPI-Linked ProteinsHumansImmunotherapyImmunotoxinsMesothelinNeoplasmsProtein Synthesis InhibitorsCTLA-4 AntigenExotoxinsGPI-Linked ProteinsImmunotoxinsMesothelinProtein Synthesis Inhibitorsanti-PD-1anti-tumor immunityimmunotherapyimmunotoxinPseudomonas exotoxin A

Identifiers

PMID30621280
PMCPMC6356957
OpenAlexW2909145676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.