Evidence map›Paper›PMID 30621135›Full record

ReviewNutrients2019

The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging.

Maaike J Bruins, Peter Van Dael, Manfred Eggersdorfer

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07373574 (Effects of the Dietary Supplements, Congaplex® and Immuplex®, on Age-Related Changes in Fingernail and Hair Health), which is not on this map. Cited by 103 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 2 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07373574 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Effects of the Dietary Supplements, Congaplex® and Immuplex®, on Age-Related Changes in Fingernail and Hair Health

TypeinterventionalSponsorStandard Process Inc.Ran2026 to 2027Enrolled0ConditionsNutrient Intake, Nutrient Intake InadequacyArmsImmune Health (Congaplex), Active Control (Gastro-Fiber), Immune Health (Immuplex)
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 2 syntheses or guidelines pooled it, 216 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effect of Heat-TreatedNutrients · 2024
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Maaike J BruinsNutrition Science & Advocacy, DSM Nutritional Products, CH-4303 Kaiseraugst, Switzerland. maaike.bruins@dsm.com.ORCID 0000-0001-9517-4617
Peter Van DaelNutrition Science & Advocacy, DSM Nutritional Products, CH-4303 Kaiseraugst, Switzerland. peter.van-dael@dsm.com.
Manfred EggersdorferUniversity Medical Center Groningen, 9713 GZ Groningen, The Netherlands. m.l.eggersdorfer@rug.nl.
DSM (Switzerland) · CHUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An increasing aging population worldwide accounts for a growing share of noncommunicable diseases (NCDs) of the overall social and economic burden. Dietary and nutritional approaches are of paramount importance in the management of NCDs. As a result, nutrition programs are increasingly integrated into public health policies. At present, programs aimed at reducing the burden of NCDs have focused mostly on the excess of unhealthy nutrient intakes whereas the importance of optimizing adequate essential and semi-essential nutrient intakes and nutrient-rich diets has received less attention. Surveys indicate that nutrient intakes of the aging population are insufficient to optimally support healthy aging. Vitamin and mineral deficiencies in older adults are related to increased risk of NCDs including fatigue, cardiovascular disease, and cognitive and neuromuscular function impairments. Reviewed literature demonstrates that improving intake for certain nutrients may be important in reducing progress of NCDs such as musculoskeletal disorders, dementia, loss of vision, and cardiometabolic diseases during aging. Current knowledge concerning improving individual nutrient intakes to reduce progression of chronic disease is still emerging with varying effect sizes and levels of evidence. Most pronounced benefits of nutrients were found in participants who had low nutrient intake or status at baseline or who had increased genetic and metabolic needs for that nutrient. Authorities should implement ways to optimize essential nutrient intake as an integral part of their strategies to address NCDs.

Indexed as

AgedAged, 80 and overAgingCardiovascular DiseasesChronic DiseaseCognition DisordersDietEye DiseasesFrail ElderlyHumansMalnutritionMusculoskeletal SystemNoncommunicable DiseasesNutrientsNutritional RequirementsNutrition PolicyNutrientsVitaminscardiovascular diseasechronic diseasedementiaeye disordersmusculoskeletal disordersnoncommunicable diseasenutrient inadequacies and deficienciesnutrient interventionspublic health

Identifiers

PMID30621135
PMCPMC6356205
OpenAlexW2907740851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.