Evidence map›Paper›PMID 30621132›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Glancing-Angle Deposition of Nanostructures on an Implant Material Surface.

Nadine Ziegler, Christina Sengstock, Viola Mai, Thomas A Schildhauer, Manfred Köller, Alfred Ludwig

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nadine ZieglerInstitute for Materials, Faculty of Mechanical Engineering, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany. nadine.ziegler@rub.de.
Christina SengstockSurgical Research, BG University Hospital Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. christina.sengstock@rub.de.
Viola MaiMathys Ltd. Bettlach, Robert Mathys Straße 5, CH-2544 Bettlach, Switzerland. viola.mai@mathysmedical.com.
Thomas A SchildhauerSurgical Research, BG University Hospital Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. thomas.a.schildhauer@rub.de.ORCID 0000-0002-3232-9869
Manfred KöllerSurgical Research, BG University Hospital Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. manfred.koeller@rub.de.ORCID 0000-0002-8335-3674
Alfred LudwigInstitute for Materials, Faculty of Mechanical Engineering, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany. alfred.ludwig@rub.de.ORCID 0000-0003-2802-6774

Funding

Deutsche Forschungsgemeinschaft LU1175/21-1 and KO 1302/8-1
6 · The paper itself

Abstract

Cell-compatible and antibacterial surfaces are needed for implants, which frequently have complex and rough surfaces. Bio-inspired columnar nanostructures can be grown on flat substrates; however, the application of these nanostructures on clinically relevant, complex, and rough surfaces was pending. Therefore, a titanium plasma spray (TPS) implant surface was coated with titanium nano-spikes via glancing angle magnetron sputter deposition (GLAD) at room temperature. Using GLAD, it was possible to cover the three-dimensional, highly structured macroscopic surface (including cavities, niches, clefts, and curved areas) of the TPS homogeneously with nano-spikes (TPS+), creating a cell-compatible and antibacterial surface. The adherence and spreading of mesenchymal stem cells (MSC) were similar for TPS and TPS+ surfaces. However, MSC adherent to TPS+ expressed less and shorter pseudopodia. The induced osteogenic response of MSC was significantly increased in cells cultivated on TPS+ compared with TPS. In addition, Gram-negative bacteria (

Indexed as

antibacterial effectcell compatibilityglancing angle depositionnanostructuressputtering

Identifiers

PMID30621132
PMCPMC6358796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.