Observational studyHIV medicine2019
Cardiovascular disease-related mortality and factors associated with cardiovascular events in the TREAT Asia HIV Observational Database (TAHOD).
Observational study in HIV medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Switching protease inhibitors to rilpivirine in HIV-positive individuals with complete viral suppression and without prior HIV drug resistance in a resource-limited setting: a randomized controlled trial.Journal of the International AIDS Society · 2020Trial
- Lipid profile dynamics and associated cardiovascular disease risk indices in Chinese people living with human immunodeficiency virus receiving antiretroviral therapy.BMC infectious diseases · 2026Article
- Major adverse cardiovascular events, morbidity, and mortality, among people living with and without HIV in two northern Uganda hospitals.BMC infectious diseases · 2026Article
- Low Cholesterol Associated With TB in People Living With HIV in an Asia-Pacific Cohort.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Article
- Association between cardio-ankle vascular index and cardiometabolic risk factors in HIV patients in Ghana.The Libyan journal of medicine · 2023Article
- Demographic and clinical characteristics associated with tobacco smoking and alcohol use disorder among heterosexual people living with HIV in West Papua, Indonesia.Journal of preventive medicine and hygiene · 2023Article
- Article
- The effects of ART on the dynamics of lipid profiles in Chinese Han HIV-infected patients: comparison between NRTI/NNRTI and NRTI/INSTI.Frontiers in public health · 2023Article
- The Role of Age in Subclinical Atherosclerosis in Asian People Living with Human Immunodeficiency Virus.Infection & chemotherapy · 2022Article
- Weight changes, metabolic syndrome and all-cause mortality among Asian adults living with HIV.HIV medicine · 2022Article
- Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy.Aging · 2021Article
- Contributory role of ART in the development of non-AIDS comorbidities in asymptomatic PLWHA.Journal of applied biomedicine · 2021Article
- Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- A retrospective analysis of the care cascades for non-communicable disease and mental health among people living with HIV at a tertiary-care centre in Malaysia: opportunities to identify gaps and optimize care.Journal of the International AIDS Society · 2020Article
- Cardiovascular disease among people living with HIV in Brazil.Tropical medicine & international health : TM & IH · 2020Article
- Statins for atherosclerotic cardiovascular disease prevention in people living with HIV in Thailand: a cost-effectiveness analysis.Journal of the International AIDS Society · 2020Article
- Atherosclerotic cardiovascular disease screening and management protocols among adult HIV clinics in Asia.Journal of virus eradication · 2020Article
- Incidence of stroke in patients with HIV infection: A population-based study in Taiwan.PloS one · 2019Article
Corrections and comments
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Authors and funding
25 authors at 20 institutions in 13 countries.
Funding
Abstract
objectivesWith aging of the HIV-positive population, cardiovascular disease (CVD) increasingly contributes to morbidity and mortality. We investigated CVD-related and other causes of death (CODs) and factors associated with CVD in a multi-country Asian HIV-positive cohort.
methodsPatient data from 2003-2017 were obtained from the Therapeutics, Research, Education and AIDS Training in Asia (TREAT Asia) HIV Observational Database (TAHOD). We included patients on antiretroviral therapy (ART) with > 1 day of follow-up. Cumulative incidences were plotted for CVD-related, AIDS-related, non-AIDS-related, and unknown CODs, and any CVD (i.e. fatal and nonfatal). Competing risk regression was used to assess risk factors of any CVD.
resultsOf 8069 patients with a median follow-up of 7.3 years [interquartile range (IQR) 4.4-10.7 years], 378 patients died [incidence rate (IR) 6.2 per 1000 person-years (PY)], and this total included 22 CVD-related deaths (IR 0.36 per 1000 PY). Factors significantly associated with any CVD event (IR 2.2 per 1000 PY) were older age [sub-hazard ratio (sHR) 2.21; 95% confidence interval (CI) 1.36-3.58 for age 41-50 years; sHR 5.52; 95% CI 3.43-8.91 for ≥ 51 years, compared with < 40 years], high blood pressure (sHR 1.62; 95% CI 1.04-2.52), high total cholesterol (sHR 1.89; 95% CI 1.27-2.82), high triglycerides (sHR 1.55; 95% CI 1.02-2.37) and high body mass index (BMI) (sHR 1.66; 95% CI 1.12-2.46). CVD crude IRs were lower in the later ART initiation period and in lower middle- and upper middle-income countries.
conclusionsThe development of fatal and nonfatal CVD events in our cohort was associated with older age, and treatable risk factors such as high blood pressure, triglycerides, total cholesterol and BMI. Lower CVD event rates in middle-income countries may indicate under-diagnosis of CVD in Asian-Pacific resource-limited settings.
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