Evidence map›Paper›PMID 30620000›Full record

ArticleHepatology communications2019

Genes and Pathways Promoting Long-Term Liver Repopulation by

Esther A Peterson, Zsuzsanna Polgar, Gnanapackiam S Devakanmalai, Yanfeng Li, Fadi L Jaber, Wei Zhang, Xia Wang, Niloy J Iqbal, John W Murray, Namita Roy-Chowdhury and 9 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Esther A PetersonDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Zsuzsanna PolgarDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Gnanapackiam S DevakanmalaiDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Yanfeng LiDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Fadi L JaberDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Wei ZhangDepartment of Radiation Oncology Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Xia WangDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Niloy J IqbalDepartment of Developmental and Molecular Biology Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
John W MurrayDepartment of Anatomy and Structural Biology Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Namita Roy-ChowdhuryDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Wilber Quispe-TintayaDepartment of Genetics Albert Einstein College of Medicine Bronx NY.
Alexander Y MaslovDepartment of Genetics Albert Einstein College of Medicine Bronx NY.
Tatyana L TchaikovskayaDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Yogeshwar SharmaDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Leslie E RoglerDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Sanjeev GuptaDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Liang ZhuDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Jayanta Roy-ChowdhuryDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.ORCID 0000-0002-8097-9225
David A ShafritzDepartment of Medicine Marion Bessin Liver Research Center, Albert Einstein College of Medicine Bronx NY.
Albert Einstein College of Medicine · US

Funding

Special Animal CoreP30DK041296 · NIDDK · YESHIVA UNIVERSITY · PI WOLKOFF, ALLAN W · 1989 to 2018
$22.9M
Transplantation of Endothelial CellsR01DK071111 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUPTA, SANJEEV · 2006 to 2016
$3.6M
GENETICALLY MODIFIED HEPATOCYTES TO ACHIEVE SUCCESS IN LIVER CELL TRANSPLANTATIONR01DK100490 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAFRITZ, DAVID A, ZHU, LIANG · 2014 to 2016
$2.0M
Deriving hepatocytes from disease specific iPS to treat metabolic liver disordersR01DK092469 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ROY-CHOWDHURY, NAMITA · 2013 to 2016
$1.8M
NIDDK NIH HHS P30 DK041296NIDDK NIH HHS R01 DK071111NIDDK NIH HHS R01 DK092469NIDDK NIH HHS R01 DK100490
6 · The paper itself

Abstract

Hepatocyte transplantation is an attractive alternative to liver transplantation. Thus far, however, extensive liver repopulation by adult hepatocytes has required ongoing genetic, physical, or chemical injury to host liver. We hypothesized that providing a regulated proliferative and/or survival advantage to transplanted hepatocytes should enable repopulation in a normal liver microenvironment. Here, we repopulated livers of DPPIV

Identifiers

PMID30620000
PMCPMC6312667
OpenAlexW2900841410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.