ArticlePhysical review. E2018
Heterogeneity and nonaffinity of cell-induced matrix displacements.
Article in Physical review. E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cell-Extracellular Matrix Feedback Results in Spontaneous Cell Polarization and Heterogeneous Remodeling in 3D Isotropic and Aligned Discrete-Fiber Models of Cell-Mediated Remodeling.Cellular and molecular bioengineering · 2026Article
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Effect of hyaluronic acid on microscale deformations of collagen gels.Journal of the mechanical behavior of biomedical materials · 2022Article
- Random Fiber Network Loaded by a Point Force.Journal of applied mechanics · 2022Article
- Effect of matrix heterogeneity on cell mechanosensing.Soft matter · 2021Article
- A computational framework for modeling cell-matrix interactions in soft biological tissues.Biomechanics and modeling in mechanobiology · 2021Article
- Directional cues in the tumor microenvironment due to cell contraction against aligned collagen fibers.Acta biomaterialia · 2021Article
- Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix.Journal of the Royal Society, Interface · 2021Article
- Non-affinity in multi-material mechanical metamaterials.Scientific reports · 2020Article
- Modulus of Fibrous Collagen at the Length Scale of a Cell.Experimental mechanics · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cell contractile forces deform and reorganize the surrounding matrix, but the relationship between the forces and the resulting displacements is complicated by the fact that the fibrous structure brings about a complex set of mechanical properties. Many studies have quantified nonlinear and time-dependent properties at macroscopic scales, but it is unclear whether macroscopic properties apply to the scale of a cell, where the matrix is composed of a heterogeneous network of fibers. To address this question, we mimicked the contraction of a cell embedded within a fibrous collagen matrix and quantified the resulting displacements. The data revealed displacements that were heterogeneous and nonaffine. The heterogeneity was reproducible during cyclic loading, and it decreased with decreasing fiber length. Both the experiments and a fiber network model showed that the heterogeneous displacements decayed over distance at a rate no faster than the average displacement field, indicating no transition to homogeneous continuum behavior. Experiments with cells fully embedded in collagen matrices revealed the presence of heterogeneous displacements as well, exposing the dramatic heterogeneity in matrix reorganization that is induced by cells at different positions within the same fibrous matrix.
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