ReviewFrontiers in molecular biosciences2018
The Evolution and the Advantages of MicroED.
Review in Frontiers in molecular biosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Practical crystallography with a transmission electron microscope.Journal of microscopy · 2026Article
- A comparison of microcrystal electron diffraction and X-ray powder diffraction for the structural analysis of metal-organic frameworks.Journal of applied crystallography · 2025Article
- Single-Crystal Structural Analysis of 2D Metal-Organic Frameworks and Covalent Organic Frameworks by Three-Dimensional Electron Diffraction.Accounts of chemical research · 2024Article
- AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography.Acta crystallographica. Section D, Structural biology · 2024Article
- Cryo-electron tomography related radiation-damage parameters for individual-molecule 3D structure determination.Frontiers in chemistry · 2022Review
- Analysis and comparison of electron radiation damage assessments in Cryo-EM by single particle analysis and micro-crystal electron diffraction.Frontiers in molecular biosciences · 2022Review
- Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures.Chemistry of materials : a publication of the American Chemical Society · 2021Article
- Protein and Organic-Molecular Crystallography With 300kV Electrons on a Direct Electron Detector.Frontiers in molecular biosciences · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
MicroED is a method which combines cryo-EM sample preparation and instrumentation, with electron and X-ray crystallography data analysis, and it has been employed to solve many protein crystal structures at high resolution. Initially, the main doubts of this method for structure determination were the dynamic scattering of electrons, which would cause severe inaccuracies in the measured intensities. In this paper, we will review the evolution of MicroED data collection and processing, the major differences of multiple scattering effects in protein crystals and inorganic material, and the advantages of continuous rotation data collection. Additionally, because of the periodic nature of the crystalline sample, radiation doses can be kept significantly lower than those used in single particle data collection. We review the work where this was used to assess the radiation damage of a high-energy electron beam on the protein molecules at much lower dose ranges compared to imaging.
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Registered trials
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