ArticleFrontiers in nutrition2018
Efficacy of a Therapeutic Diet on Dogs With Signs of Cognitive Dysfunction Syndrome (CDS): A Prospective Double Blinded Placebo Controlled Clinical Study.
Article in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals.GeroScience · 2025Pooled it
- Pet Nutrition and the Unmeasured Owner Outcome: A Bidirectional Framework for Relational Value in Human-Animal Relationships.Animals : an open access journal from MDPI · 2026Review
- Evidence-Based Clinical Management of Canine Cognitive Dysfunction Syndrome: Diagnostic Algorithms, Practical Guidelines, Critical Appraisal of Biomarkers and Translational Limitations.Animals : an open access journal from MDPI · 2026Review
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Does the definition of human ultra-processed foods apply to dog and cat foods? A review of pet food processing techniques, their impact on health, and a call for pet food processing classification.Frontiers in veterinary science · 2026Article
- Quantifying placebo and trial participation effects on cognitive outcome measures in aging dogs.GeroScience · 2025Article
- Unveiling the significance of dog domestication in cognitive dysfunction: Are wolves protected?Open veterinary journal · 2025Article
- Current practices for diagnosis and management of Canine Cognitive Dysfunction Syndrome in the United States.Frontiers in veterinary science · 2025Article
- Feline Cognition and the Role of Nutrition: An Evolutionary Perspective and Historical Review.Animals : an open access journal from MDPI · 2024Review
- Nutritional needs and health outcomes of ageing cats and dogs: is it time for updated nutrient guidelines?Animal frontiers : the review magazine of animal agriculture · 2024Article
- Transcranial photobiomodulation therapy improves cognitive test scores in dogs with presumptive canine cognitive dysfunction: A case series of five dogs.Open veterinary journal · 2024Article
- Roles of Nutrients in the Brain Development, Cognitive Function, and Mood of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Comparing standard screening questionnaires of canine behavior for assessment of cognitive dysfunction.Frontiers in veterinary science · 2024Article
- Nutrition and Aging in Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Recent Advances in the Nutrition and Metabolism of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- Investigating Owner Use of Dietary Supplements in Dogs with Canine Cognitive Dysfunction.Animals : an open access journal from MDPI · 2023Article
- Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project.GeroScience · 2023Observational
- Dietary Strategies for Relieving Stress in Pet Dogs and Cats.Antioxidants (Basel, Switzerland) · 2023Review
- Oral administration of an integrative supplement (CogniCapsOpen veterinary journal · 2023Article
- Evaluation of Two Practical Tools to Assess Cognitive Impairment in Aged Dogs.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive dysfunction syndrome (CDS) is a common condition in senior dogs, which may be analogous to dementia such as Alzheimer's disease (AD) in people. In humans, AD has been associated with many risk factors such as reduced cerebral glucose metabolism, docosahexaenoic acid (DHA) deficiency, chronic oxidative stress, and chronic inflammation. By targeting some of these risk factors, we have developed two nutritional solutions (medium chain triglyceride, MCT and Brain Protection Blend, BPB) to enhance cognitive function and slow aging-induced cognitive decline. These have been positively evaluated in colony housed senior dogs and cats. The objective of this clinical study was to evaluate the effects of diets with MCTs and the BPB on client-owned dogs with CDS. Participating veterinary clinics screened senior dogs for signs of CDS as determined by a Senior Canine Behavior Questionnaire and a Canine Medical Health Questionnaire. Eighty-seven dogs were randomly enrolled into one of three diet groups with 29 dogs per group: Control, 6.5% MCT oil + BPB (6.5% MCT diet), 9% MCT oil + BPB (9% MCT diet). Diets were fed for a period of 90 days, and each dog's CDS signs were re-evaluated at day 30 and day 90. All 6 categories of the CDS signs were significantly improved (
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