ReviewFrontiers in medicine2018
Current Understanding of How Extracorporeal Membrane Oxygenators Activate Haemostasis and Other Blood Components.
Review in Frontiers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04997265 (Strategies for Anticoagulation During Venovenous ECMO), which is not on this map. Cited by 108 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strategies for Anticoagulation During Venovenous ECMO: The SAFE-ECMO Pilot Trial
Who cites it
108 citing papers in PubMed, 1 synthesis or guideline pooled it, 219 citations in OpenAlex.
- Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis.Perfusion · 2021Pooled it
- Trial
- Trial
- Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study.Scientific reports · 2021Trial
- Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep.Annals of biomedical engineering · 2026Article
- Article
- From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting.Antioxidants (Basel, Switzerland) · 2026Review
- Population Pharmacokinetics of Ticagrelor during Veno-Arterial ECMO in Acute Coronary Syndrome: Model-Informed Dosing Simulations.Clinical pharmacology and therapeutics · 2026Observational
- Development of a novel anticoagulant and fibrinolytic management monitoring method during extracorporeal circulation using clot-fibrinolysis waveform analysis: the effects of anticoagulants on coagulation and fibrinolysis functions.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Nitric Oxide-Releasing Surfaces Reduce Thrombosis in Venovenous Extracorporeal Life Support: A 5 day Long Ovine Study.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Impact of eosinophil levels on postoperative clinical outcomes in patients undergoing extracorporeal circulation: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Daily biomarker trajectories predict major bleeding in patients on venovenous ECMO for ARDS: a retrospective longitudinal cohort study.Scientific reports · 2026Article
- Unlucky for some? Bleeding associated with factor XIII deficiency during extracorporeal membrane oxygenation.Research and practice in thrombosis and haemostasis · 2026Article
- Early red blood cell transfusion burden, hemoglobin at first transfusion, and in-hospital mortality in patients supported with veno-arterial ECMO: a multicenter cohort study.Annals of intensive care · 2026Article
- Mortality and complications in low-dose vs standard-dose unfractionated heparin anticoagulation for extracorporeal membrane oxygenation: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2026Article
- Polymer embedding of membrane lungs for histological investigations of intra-device clot formation.Frontiers in cardiovascular medicine · 2026Article
- Surgical intervention with cardiopulmonary bypass in a patient with von Willebrand disease.BMC anesthesiology · 2025Article
- Anticoagulation-free strategy within the first 24 h of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest patients: a retrospective cohort study.European journal of medical research · 2025Article
- Outcomes and survival prediction in adults with sickle cell disease treated with extracorporeal membrane oxygenation.Blood advances · 2025Observational
- Incidence of neutrophil extracellular traps (NETs) in different membrane oxygenators: pilot in vitro experiments in commercially available coated membranes.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracorporeal membrane oxygenators are used in critical care for the management of severe respiratory and cardiac failure. Activation of the coagulation system is initiated by the exposure of blood to synthetic surfaces and the shear stresses of the circuit, especially from device pumps. Initial fibrinogen deposition and subsequent activation of coagulation factors and complement allow platelets and leucocytes to adhere to oxygenator surfaces and enhance thrombin generation. These changes and others contribute to higher rates of thrombosis seen in these patients. In addition, bleeding rates are also high. Primary haemostasis is impaired by platelet dysfunction and loss of their key adhesive molecules and shear stress causes an acquired von Willebrand defect. In addition, there is also altered fibrinolysis and lastly, administration of systemic anticoagulation is required to maintain circuit patency. Further research is required to fulyl establish the complexities of the haemostatic changes with these devices, and to elucidate the mechanistic changes that are mainly responsible so that plans can be made to reduce their complications and improve management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.