Evidence map›Paper›PMID 30619652›Full record

ArticleTranslational vision science & technology2018

Ocular Spot Fluorometer Equipped With a Lock-In Amplifier for Measurement of Aqueous Flare.

Rachapalle Reddi Sudhir, P Pavani Murthy, Sirisha Tadepalli, Subashree Murugan, Prema Padmanabhan, Ashwini Krishnamurthy, Stephanie L Dickinson, R Karthikeyan, Uday B Kompella, Sangly P Srinivas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Rachapalle Reddi SudhirDepartment of Cornea and Refractive Surgery, Sankara Nethralaya, Chennai, India.
P Pavani MurthyDepartment of Cornea and Refractive Surgery, Sankara Nethralaya, Chennai, India.
Sirisha TadepalliDepartment of Electronics and Communication Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru, India.
Subashree MuruganSchool of Optometry, Indiana University, Bloomington, IN, USA.
Prema PadmanabhanDepartment of Cornea and Refractive Surgery, Sankara Nethralaya, Chennai, India.
Ashwini KrishnamurthyDepartment of Cornea and Refractive Surgery, Sankara Nethralaya, Chennai, India.
Stephanie L DickinsonSchool of Public Health, Indiana University, Bloomington, IN, USA.
R KarthikeyanDepartment of Electronics and Communication Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru, India.
Uday B KompellaPharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Sangly P SrinivasSchool of Optometry, Indiana University, Bloomington, IN, USA.
Sankara Nethralaya · INIndiana University Bloomington · USAmrita Vishwa Vidyapeetham · INUniversity of Colorado Anschutz Medical Campus · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
NCATS NIH HHS UL1 TR001108
6 · The paper itself

Abstract

purposeTo evaluate a custom-made ocular fluorometer for detection of intensity of light scatter (ILS) from the anterior chamber (A/C) as an objective measure of aqueous flare.

methodsThe fluorometer, equipped with a lock-in amplifier, was employed in the scatter mode to detect ILS from A/C. Measurements were performed with two illumination slit widths of 0.5 and 0.25 mm. The axial resolution at these slit widths were 80 and 200 μm, respectively. Healthy and pseudophakic eyes, with grade 0 Standardization of Uveitis Nomenclature (SUN) score, were employed as control subjects. ILS was also recorded in a cohort of patients who had undergone phacoemulsification and showed grades 1+ or 2+ on postoperative days 1 and 4.

resultsThe inter- and intraobserver variabilities in the measurement of ILS were not significant. In cataract patients, ILS was significantly higher on postoperative day 1 relative to healthy eyes. By day 4, ILS decreased significantly and was only marginally different from ILS in quiet pseudophakic eyes or healthy eyes. Eyes with higher SUN scores showed proportionately increased ILS. The receiver-operator characteristic analysis indicated no advantage in using the smaller slit width in discriminating ILS at different SUN scores although it provided higher axial resolution.

conclusionsThe lock-in-based spot fluorometer is reliable for measurement of ILS with high precision and accuracy.The measured ILS correlates linearly with SUN scores and can be used to provide a higher granularity for recording aqueous flare. TRANSLATIONAL RELEVANCE: The instrument can be used in the clinical management of uveitis and drug development toward uveitis.

Indexed as

aqueous flareblood–aqueous barrierlight scatterlock-in amplifierocular fluorometerSUN gradinguveitis

Identifiers

PMID30619652
PMCPMC6314058
OpenAlexW2905607388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.