ArticleTranslational vision science & technology2018
A New in Vitro Model of GDLD by Knocking Out
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
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Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that causes severe vision loss. Because of its poor prognosis, there is a demand for novel treatments for GDLD. Here, we establish a new in vitro disease model of GDLD based on immortalized human corneal epithelial (HCE-T) cells.
methodsBy using transcription activator-like effector nuclease plasmids, tumor-associated calcium signal transducer 2 (
resultsDKO cells exhibited decreased expression and aberrant subcellular localization of CLDN1 and CLDN7 proteins, as well as decreased epithelial barrier function. Transduction of the
conclusionsWe established an in vitro disease model of GDLD by knocking out TRANSLATIONAL RELEVANCE: We expect that the cell line will be useful to elucidate the pathogenesis of GDLD and develop novel treatments for GDLD.
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Registered trials
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