ArticleTranslational vision science & technology2018
Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The luminance-response function of the photopic negative response (PhNR): analysing different stimulation, recording and measurement approaches.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Computer-Aided Discrimination of Glaucoma Patients from Healthy Subjects Using the RETeval Portable Device.Diagnostics (Basel, Switzerland) · 2024Article
- Early changes in photopic negative response in eyes with glaucoma with and without choroidal detachment after filtration surgery.The British journal of ophthalmology · 2023Observational
- Investigating the Structural and Functional Changes in the Optic Nerve in Patients with Early Glaucoma Using the Optical Coherence Tomography (OCT) and RETeval System.Sensors (Basel, Switzerland) · 2023Article
- Single opsin driven white noise ERGs in mice.Frontiers in neuroscience · 2023Article
- Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.Ophthalmology science · 2021Article
- Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.Translational vision science & technology · 2020Review
- Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.Translational vision science & technology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the effect of interstimulus frequency on the photopic negative response (PhNR) in the clinical electroretinogram (ERG) in glaucoma and healthy eyes.
methodsParticipants with open angle glaucoma (
resultsWhile the a-wave and b-wave showed minimal alteration, the PhNR was highly sensitive to changes in interstimulus frequency. The PhNR signal was largest at 1 Hz and steadily diminished with higher frequencies in both control and glaucoma groups. Significant differences in PhNR amplitude were found between controls and glaucoma groups at 2 and 3 Hz. While 1 Hz delivered the largest PhNR, it also showed a significantly greater CoV compared to other frequencies.
conclusionsAn interstimulus frequency of 2 Hz was optimal for recording the PhNR, creating a good balance between testing time and signal quality. A higher frequency could be used to further shorten clinical testing times; however, this may compromise its clinical utility by dampening the PhNR. TRANSLATIONAL RELEVANCE: Here we show the importance of considering flash interstimulus frequency when designing ERG protocols for recording the PhNR as while higher frequencies can shorten test times, they also have considerable effects on the PhNR.
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