Evidence map›Paper›PMID 30619611›Full record

ArticlePharmacology research & perspectives2019

Diazepam is not a direct allosteric modulator of α

Lisa M Williams, Xiaoji He, Tasneem M Vaid, Alaa Abdul-Ridha, Alice R Whitehead, Paul R Gooley, Ross A D Bathgate, Spencer J Williams, Daniel J Scott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Diazepam is not a direct allosteric modulator of αPharmacology research & perspectives · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lisa M WilliamsThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.
Xiaoji HeThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.
Tasneem M VaidThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.
Alaa Abdul-RidhaThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.
Alice R WhiteheadThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.
Paul R GooleyDepartment of Biochemistry and Molecular Biology University of Melbourne Parkville Vic Australia.ORCID 0000-0002-0323-449X
Ross A D BathgateThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.ORCID 0000-0001-6301-861X
Spencer J WilliamsSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute University of Melbourne Parkville Vic Australia.ORCID 0000-0001-6341-4364
Daniel J ScottThe Florey Institute of Neuroscience and Mental Health University of Melbourne Parkville Vic Australia.ORCID 0000-0001-6332-2793
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α

Indexed as

Allosteric RegulationAnimalsBinding SitesChlorocebus aethiopsCOS CellsCyclic Nucleotide Phosphodiesterases, Type 4DiazepamHEK293 CellsHumansMagnetic Resonance SpectroscopyPhosphodiesterase 4 InhibitorsReceptors, Adrenergic, alpha-1ADRA1A protein, humanADRA1B protein, humanCyclic Nucleotide Phosphodiesterases, Type 4DiazepamPhosphodiesterase 4 InhibitorsReceptors, Adrenergic, alpha-1allosteric modulatorbenzodiazepinesGPR68phosphodiesterasethermostabilized receptorα1 adrenergic receptorsα1‐adrenoceptors

Identifiers

PMID30619611
PMCPMC6306559
OpenAlexW2908237892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.