Evidence map›Paper›PMID 30619375›Full record

ArticleFrontiers in immunology2018

IL-6 Impairs Vaccine Responses in Neonatal Mice.

Jiyeon Yang, Jiro Sakai, Shafiuddin Siddiqui, Robert C Lee, Derek D C Ireland, Daniela Verthelyi, Mustafa Akkoyunlu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. The Ability of Neonatal Mice to Develop Immunity toJournal of cellular immunology · 2025
    Article
  4. State of pneumococcal vaccine immunity.Human vaccines & immunotherapeutics · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Effect of DietaryFrontiers in veterinary science · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jiyeon YangDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Jiro SakaiDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Shafiuddin SiddiquiDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Robert C LeeDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Derek D C IrelandOffice of Biotechnology Products, Division of Biotechnology Review and Research III, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Daniela VerthelyiOffice of Biotechnology Products, Division of Biotechnology Review and Research III, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Mustafa AkkoyunluDivision of Bacterial Allergenic and Parasitic Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.
Center for Biologics Evaluation and Research · USUnited States Food and Drug Administration · USCenter for Drug Evaluation and Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inability of infants to mount proper follicular helper T (T

Indexed as

Immunogenicity, VaccineAge FactorsAnimalsAnimals, NewbornCell DifferentiationFemaleGerminal CenterInterleukin-21Interleukin-21 Receptor alpha SubunitInterleukin-6InterleukinsMeningococcal VaccinesMiceMice, Inbred C57BLModels, AnimalReceptors, Interleukin-6Il21r protein, mouseInterleukin-21Interleukin-21 Receptor alpha SubunitInterleukin-6InterleukinsMeningococcal VaccinesReceptors, Interleukin-6Recombinant ProteinsTetanus ToxoidVaccines, Combinedfollicular helper T cellfollicular regulatory helper T cellIL-6neonatesvaccine

Identifiers

PMID30619375
PMCPMC6307459
OpenAlexW2906574715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.