Evidence map›Paper›PMID 30619373›Full record

ArticleFrontiers in immunology2018

Fas Signaling in Dendritic Cells Mediates Th2 Polarization in HDM-Induced Allergic Pulmonary Inflammation.

Miaomiao Han, Ran Hu, Jingyu Ma, Baohua Zhang, Ce Chen, Huabin Li, Jun Yang, Gonghua Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Miaomiao HanDepartment of Otolaryngology-Head and Neck Surgery, Center for Allergic and Inflammatory Diseases, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.
Ran HuShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingyu MaShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Baohua ZhangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ce ChenGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China.
Huabin LiDepartment of Otolaryngology-Head and Neck Surgery, Center for Allergic and Inflammatory Diseases, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China.
Jun YangXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gonghua HuangShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University · CNXinHua Hospital · CNEye & ENT Hospital of Fudan University · CNGuangdong Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fas-Fas ligand (FasL) signaling plays an important role in the development of allergic inflammation, but the cellular and molecular mechanisms are still not well known. By using the bone marrow-derived dendritic cell (BMDC) transfer-induced pulmonary inflammation model, we found that house dust mite (HDM)-stimulated FAS-deficient BMDCs induced higher Th2-mediated allergic inflammation, associated with increased mucus production and eosinophilic inflammation. Moreover, FAS-deficient BMDCs promoted Th2 cell differentiation upon HDM stimulation

Indexed as

Adoptive TransferAnimalsBronchoalveolar Lavage FluidCell CommunicationCell DifferentiationDendritic CellsDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesFas Ligand Proteinfas ReceptorHumansHypersensitivityLungLymphocyte ActivationMAP Kinase Signaling SystemMiceExtracellular Signal-Regulated MAP KinasesFas Ligand ProteinFasl protein, mouseFas protein, mousefas Receptorallergic inflammationdendritic cellsFashouse dust miteTh2

Identifiers

PMID30619373
PMCPMC6308134
OpenAlexW2906573949

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.