Evidence map›Paper›PMID 30619336›Full record

ArticleFrontiers in immunology2018

Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis.

Chieh-Yu Liao, Myeong Jun Song, Yandong Gao, Amy S Mauer, Alexander Revzin, Harmeet Malhi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Circulating Liver-Derived and CD36Journal of extracellular vesicles · 2026
    Article
  5. F13A1-Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Innate Immunity and MASLD.Biomolecules · 2024
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chieh-Yu LiaoDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Myeong Jun SongDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Yandong GaoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
Amy S MauerDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Alexander RevzinDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States.
Harmeet MalhiDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
Pathobiology of Liver InjuryR01DK111378 · NIDDK · MAYO CLINIC ROCHESTER · PI MALHI, HARMEET · 2016 to 2025
$3.9M
NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK111378
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell LineChemotaxisDiet, AtherogenicDiet, Carbohydrate LoadingDiet, High-FatDisease Models, AnimalExtracellular VesiclesGene Knockout TechniquesHepatocytesHumansLiverLysophospholipidsMacrophagesMaleMiceLysophospholipidsPalmitic AcidReceptors, LysosphingolipidS1pr1 protein, mouseSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptorsceramidenon-alcoholic steatohepatitispalmitic acidsphingolipid signalingsphingosine kinase

Identifiers

PMID30619336
PMCPMC6305739
OpenAlexW2904701752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.