Evidence map›Paper›PMID 30619266›Full record

ArticleFrontiers in immunology2018

Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.

Paula Kuo, Siok Min Teoh, Zewen K Tuong, Graham R Leggatt, Stephen R Mattarollo, Ian H Frazer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Immunotherapy for HPV associated cancer.Papillomavirus research (Amsterdam, Netherlands) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paula KuoTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Siok Min TeohTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Zewen K TuongTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Graham R LeggattTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Stephen R MattarolloTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Ian H FrazerTranslational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
Translational Research Institute · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"High-risk" human papillomaviruses (HPV) infect keratinocytes of squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and disrupting cell cycle termination. Murine skin expressing HPV16E7 as a transgene from a keratin 14 promoter (K14.E7) demonstrates epithelial hyperplasia, dysfunctional antigen presenting cells, ineffective antigen presentation by keratinocytes, and production of immunoregulatory cytokines. Furthermore, grafted K14.E7 skin is not rejected from immunocompetent non-transgenic recipient animals. To establish the contributions of E7, of E7-Rb interaction and of epithelial hyperplasia to altered local skin immunity, K14.E7 skin was compared with skin from K14.E7 mice heterozygous for a mutant Rb unable to bind E7 (K14.E7xRb

Indexed as

AnimalsAntigen-Presenting CellsDisease Models, AnimalEpidermisFemaleHuman papillomavirus 16HumansHyperplasiaKeratinocytesLymph NodesMiceMice, Inbred C57BLMice, TransgenicPapillomavirus E7 ProteinsPapillomavirus InfectionsProtein Bindingoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsRb1 protein, mouseRetinoblastoma Binding ProteinsRetinoblastoma ProteinAPCCINHPV16keratinocytesretinoblastoma proteinskin grafting

Identifiers

PMID30619266
PMCPMC6305623
OpenAlexW2904034072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.