ReviewFrontiers in immunology2018
Circumventricular Organs and Parasite Neurotropism: Neglected Gates to the Brain?
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 59 citations in OpenAlex.
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- MicroRNA-Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery.Brain and behavior · 2026Review
- Neuroinflammation in fungal infections: from pathogen recognition to pathological manifestations.Disease models & mechanisms · 2025Review
- 'Un-thirsty' hypernatremia.Endocrinology, diabetes & metabolism case reports · 2025Article
- Refractory Nausea and Vomiting Due to Central Nervous System Injury: A Focused Review.Life (Basel, Switzerland) · 2025Review
- Cryptococcal Choroid Plexitis and Ependymitis in Progressive Dementia.Internal medicine (Tokyo, Japan) · 2025Article
- Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Transnasal drug delivery to the brain: circumventing barriers for brain tumor patients.American journal of translational research · 2025Review
- Case Report: Hypothalamic demyelinating lesion preceding lymphoma arising outside the central nervous system.Frontiers in oncology · 2025Article
- Interactions between sleep, inflammation, immunity and infections: A narrative review.Immunity, inflammation and disease · 2024Review
- Unraveling the SARS-CoV-2 spike protein long-term effect on neuro-PASC.Frontiers in cellular neuroscience · 2024Article
- Investigation ofCell surface (Amsterdam, Netherlands) · 2023Article
- Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Could the Urease of the Gut BacteriumMicroorganisms · 2023Article
- Parasite effects on receivers in animal communication: Hidden impacts on behavior, ecology, and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ependyma in Neurodegenerative Diseases, Radiation-Induced Brain Injury and as a Therapeutic Target for Neurotrophic Factors.Biomolecules · 2023Review
- Live imaging of microglia during sleeping sickness reveals early and heterogeneous inflammatory responses.Frontiers in immunology · 2023Article
- Lymphocytic hypophysitis in dogs infected withFrontiers in veterinary science · 2023Article
- Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection.Nature communications · 2022Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circumventricular organs (CVOs), neural structures located around the third and fourth ventricles, harbor, similarly to the choroid plexus, vessels devoid of a blood-brain barrier (BBB). This enables them to sense immune-stimulatory molecules in the blood circulation, but may also increase chances of exposure to microbes. In spite of this, attacks to CVOs by microbes are rarely described. It is here highlighted that CVOs and choroid plexus can be infected by pathogens circulating in the bloodstream, providing a route for brain penetration, as shown by infections with the parasites
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.