Evidence map›Paper›PMID 30619244›Full record

ArticleFrontiers in immunology2018

Structure-Function Relationship of XCL1 Used for

Arthur L Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans W Mages, Sebastian Voigt, Christian Freund, Richard A Kroczek

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis.Basic & clinical pharmacology & toxicology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. A review of vaccinology andHuman vaccines & immunotherapeutics · 2025
    Review
  6. Article
  7. The multifaceted role of XCL1 in health and disease.Protein science : a publication of the Protein Society · 2025
    Review
  8. Article
  9. Molecular basis for chemokine recognition and activation of XCR1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Arthur L KroczekMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Evelyn HartungMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Stephanie GurkaMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Martina BeckerMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Nele ReegMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Hans W MagesMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Sebastian VoigtVirology, Robert Koch-Institute, Berlin, Germany.
Christian FreundProtein Biochemistry, Institute for Biochemistry, Free University of Berlin, Berlin, Germany.
Richard A KroczekMolecular Immunology, Robert Koch-Institute, Berlin, Germany.
Robert Koch Institute · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC. Therefore, we have functionally analyzed various XCL1 domains in highly relevant settings

Indexed as

Chemokines, CDrug CarriersOvalbuminRecombinant Fusion ProteinsAnimalsCD8-Positive T-LymphocytesCell ProliferationChemotaxisDendritic CellsMiceMice, TransgenicProtein DomainsReceptors, ChemokineStructure-Activity RelationshipVaccinesChemokines, CDrug CarriersOvalbuminReceptors, ChemokineRecombinant Fusion ProteinsVaccinesXC chemokine receptor 1, mouseXcl1 protein, mouseantigen targetingcross-presentationdendritic cellsXCL1XCR1

Identifiers

PMID30619244
PMCPMC6300513
OpenAlexW2904881174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.