ArticleFrontiers in microbiology2018
Bacterial and Archaeal Viruses of Himalayan Hot Springs at Manikaran Modulate Host Genomes.
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Bacteriophage research in India and its implications for human health: A scoping review.The Indian journal of medical research · 2026Article
- Community ecology and functional potential of bacteria, archaea, eukarya and viruses in Guerrero Negro microbial mat.Scientific reports · 2024Article
- Metaviromic analyses of DNA virus community from sediments of the N-Choe stream, North India.Virus research · 2023Article
- Viruses Regulate Microbial Community Assembly Together with Environmental Factors in Acid Mine Drainage.Applied and environmental microbiology · 2023Article
- Microbial Journey: Mount Everest to Mars.Indian journal of microbiology · 2022Review
- Metagenomic analysis of wastewater phageome from a University Hospital in Turkey.Archives of microbiology · 2022Article
- An Appraisal of Bacteriophage Isolation Techniques from Environment.Microbial ecology · 2022Review
- Unveiling Ecological and Genetic Novelty within Lytic and Lysogenic Viral Communities of Hot Spring Phototrophic Microbial Mats.Microbiology spectrum · 2021Article
- Review
- Aerobic and anaerobic iron oxidizers together drive denitrification and carbon cycling at marine iron-rich hydrothermal vents.The ISME journal · 2021Article
- Bio-imaging with the helium-ion microscope: A review.Beilstein journal of nanotechnology · 2021Review
- Insights into the dynamics between viruses and their hosts in a hot spring microbial mat.The ISME journal · 2020Article
- Metavirome and its functional diversity analysis through microbiome study of the Sikkim Himalayan hot spring solfataric mud sediments.Current research in microbial sciences · 2020Article
- Taxonomically Characterized and Validated Bacterial Species Based on 16S rRNA Gene Sequences from India During the Last Decade.Indian journal of microbiology · 2020Review
- Microbial Ecology from the Himalayan Cryosphere Perspective.Microorganisms · 2020Review
- Genome Sequencing Revealed the Biotechnological Potential of an Obligate ThermophileIndian journal of microbiology · 2019Article
- Draft Genome Sequence ofMicrobiology resource announcements · 2019Article
- A Review on Viral Metagenomics in Extreme Environments.Frontiers in microbiology · 2019Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hot spring-associated viruses, particularly the archaeal viruses, remain under-examined compared to bacteriophages. Previous metagenomic studies of the Manikaran hot springs in India suggested an abundance of viral DNA, which prompted us to examine the virus-host (bacterial and archaeal) interactions in sediment and microbial mat samples collected from the thermal discharges. Here, we characterize the viruses (both bacterial and archaeal) from this Himalayan hot spring using both metagenomics assembly and electron microscopy. We utilized four shotgun samples from sediment (78-98°C) and two from microbial mats (50°C) to reconstruct 65 bacteriophage genomes (24-200 kb). We also identified 59 archaeal viruses that were notably abundant across the sediment samples. Whole-genome analyses of the reconstructed bacteriophage genomes revealed greater genomic conservation in sediments (65%) compared to microbial mats (49%). However, a minimal phage genome was still maintained across both sediment and microbial mats suggesting a common origin. To complement the metagenomic data, scanning-electron and helium-ion microscopy were used to reveal diverse morphotypes of Caudovirales and archaeal viruses. The genome level annotations provide further evidence for gene-level exchange between virus and host in these hot springs, and augments our knowledgebase for bacteriophages, archaeal viruses and Clustered Regularly Interspaced Short Palindromic Repeat cassettes, which provide a critical resource for studying viromes in extreme natural environments.
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