Effects of FSH on Sperm DNA Fragmentation: Review of Clinical Studies and Possible Mechanisms of Action.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

1. Effect of Letrozole on sperm parameters, chromatin status and ROS level in idiopathic Oligo/Astheno/Teratozoospermia.Reproductive biology and endocrinology : RB&E · 2020
   Trial
2. Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework.Frontiers in urology · 2026
   Article
3. Effectiveness of recombinant follicle-stimulating hormone treatment in patients with oligo-asthenospermia at different levels of DNA fragmentation index: A phase II clinical trial.Current urology · 2025
   Article
4. The Importance of Discordant Follicle Stimulating Hormone and Inhibin B Levels in Primary Infertile Men: Findings from a Cross-Sectional Study.The world journal of men's health · 2025
   Article
5. Combined evaluation of prolactin-induced peptide (PIP) and extracellular signal-regulated kinase (ERK) as new sperm biomarkers of FSH treatment efficacy in normogonadotropic idiopathic infertile men.Journal of endocrinological investigation · 2024
   Article
6. Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.The world journal of men's health · 2023
   Article
7. Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023
   Article
8. The infertile individual analysis based on whole-exome sequencing in chinese multi-ethnic groups.Genes & genomics · 2023
   Article
9. The effects of hormonal changes on sperm DNA integrity in oligoasthenoteratospermia individuals: A case-control study.International journal of reproductive biomedicine · 2022
   Article
10. Letrozole, an aromatase inhibitor, improves seminal parameters and hormonal profile in aged endangered Markhoz bucks.Animal bioscience · 2022
    Article
11. Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2022
    Review
12. Sperm DNA integrity and male infertility: a narrative review and guide for the reproductive physicians.Translational andrology and urology · 2022
    Review
13. The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution.Health science reports · 2021
    Article
14. Plants (Basel, Switzerland) · 2021
    Article
15. Progress in Research on Sperm DNA Fragmentation.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
16. Clinical Use of FSH in Male Infertility.Frontiers in endocrinology · 2019
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as