ArticleFrontiers in neurology2018
Peripheral Nervous System Reconstruction Reroutes Cortical Motor Output-Brain Reorganization Uncovered by Effective Connectivity.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Functional connectivity during drawing after upper extremity peripheral nerve surgery: enhanced connectivity between motor and visuomotor-parietal regions.bioRxiv : the preprint server for biology · 2026Article
- Plasticity of the Central Nervous System Involving Peripheral Nerve Transfer.Neural plasticity · 2022Review
- Kinematic Changes in the Uninjured Limb After a Traumatic Brachial Plexus Injury.Frontiers in human neuroscience · 2021Article
- Top-down versus bottom-up attention differentially modulate frontal-parietal connectivity.Human brain mapping · 2020Article
- A New Rehabilitative Mechanism in Primary Motor Cortex After Peripheral Trauma.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Cortical reorganization in response to peripheral nervous system damage is only poorly understood. In patients with complete brachial plexus avulsion and subsequent reconnection of the end of the musculocutaneous nerve to the side of a phrenic nerve, reorganization leads to a doubled arm representation in the primary motor cortex. Despite, homuncular organization being one of the most fundamental principles of the human brain, movements of the affected arm now activate 2 loci: the completely denervated arm representation and the diaphragm representation. Here, we investigate the details behind this peripherally triggered reorganization, which happens in healthy brains. fMRI effective connectivity changes within the motor network were compared between a group of patients and age matched healthy controls at 7 Tesla (6 patients and 12 healthy controls). Results show the establishment of a driving input of the denervated arm area to the diaphragm area which is now responsible for arm movements. The findings extend current knowledge about neuroplasticity in primary motor cortex: a denervated motor area may drive an auxilliary area to reroute its motor output.
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Registered trials
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