Evidence map›Paper›PMID 30619066›Full record

ReviewFrontiers in neurology2018

A Multidimensional Approach to Post-concussion Symptoms in Mild Traumatic Brain Injury.

Suzanne Polinder, Maryse C Cnossen, Ruben G L Real, Amra Covic, Anastasia Gorbunova, Daphne C Voormolen, Christina L Master, Juanita A Haagsma, Ramon Diaz-Arrastia, Nicole von Steinbuechel

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 167 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 4 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04760899 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Bilateral Cerebellar Transcranial Direct Current Stimulation (tDCS) for the Treatment of Sports-Related Post-Concussion Syndrome (SRPCS)

TypeinterventionalSponsorUniversity of IowaRan2021 to 2027Enrolled31ConditionsPost-Concussion SyndromeArmsTranscranial Direct Current Stimulation
NCT07166536 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Mental Imagery on Headache and Dizziness in Patients With Persistent Post-concussion Symptoms

TypeinterventionalSponsorReuth Rehabilitation HospitalRan2025 to 2026Enrolled60ConditionsMild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic, Post Traumatic HeadacheArmsProvocation Test for Symptoms Using Mental Imagery
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 4 syntheses or guidelines pooled it, 364 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. The Effect of Aerobic Exercise on Concussion Recovery: A Pilot Clinical Trial.Journal of the International Neuropsychological Society : JINS · 2021
    Trial
  9. Trial
  10. Trial
  11. Review
  12. Article
  13. Article
  14. The Role of Traumatic Brain Injury on Intimate Partner Violence and Changes in Mental Health From Late Adolescence to Young Adulthood.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026
    Article
  15. Research progress on biomarkers of traumatic brain injury.Animal models and experimental medicine · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Serum Biomarkers in Paediatric Neurosurgery: Traumatic Brain Injury and Beyond.Advances and technical standards in neurosurgery · 2026
    Article
  20. Article

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Suzanne PolinderDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Maryse C CnossenDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Ruben G L RealInstitute of Medical Psychology and Medical Sociology, Georg-August-University, Göttingen, Germany.
Amra CovicInstitute of Medical Psychology and Medical Sociology, Georg-August-University, Göttingen, Germany.
Anastasia GorbunovaInstitute of Medical Psychology and Medical Sociology, Georg-August-University, Göttingen, Germany.
Daphne C VoormolenDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Christina L MasterDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Juanita A HaagsmaDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Nicole von SteinbuechelInstitute of Medical Psychology and Medical Sociology, Georg-August-University, Göttingen, Germany.
Erasmus MC · NLUniversity of Göttingen · DEUniversity of Pennsylvania · US

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) presents a substantial burden to patients, families, and health care systems. Whereas, recovery can be expected in the majority of patients, a subset continues to report persisting somatic, cognitive, emotional, and/or behavioral problems, generally referred to as post-concussion syndrome (PCS). However, this term has been the subject of debate since the mechanisms underlying post-concussion symptoms and the role of pre- and post-injury-related factors are still poorly understood. We review current evidence and controversies concerning the use of the terms post-concussion symptoms vs. syndrome, its diagnosis, etiology, prevalence, assessment, and treatment in both adults and children. Prevalence rates of post-concussion symptoms vary between 11 and 82%, depending on diagnostic criteria, population and timing of assessment. Post-concussion symptoms are dependent on complex interactions between somatic, psychological, and social factors. Progress in understanding has been hampered by inconsistent classification and variable assessment procedures. There are substantial limitations in research to date, resulting in gaps in our understanding, leading to uncertainty regarding epidemiology, etiology, prognosis, and treatment. Future directions including the identification of potential mechanisms, new imaging techniques, comprehensive, multidisciplinary assessment and treatment options are discussed. Treatment of post-concussion symptoms is highly variable, and primarily directed at symptom relief, rather than at modifying the underlying pathology. Longitudinal studies applying standardized assessment strategies, diagnoses, and evidence-based interventions are required in adult and pediatric mTBI populations to optimize recovery and reduce the substantial socio-economic burden of post-concussion symptoms.

Indexed as

diagnosisetiologymild traumatic brain injuryoutcomepost-concussion symptomsprevalencetreatment

Identifiers

PMID30619066
PMCPMC6306025
OpenAlexW2905320148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.