Evidence map›Paper›PMID 30618845›Full record

ArticleFrontiers in physiology2018

The Case Study of Nesfatin-1 in the Pancreas of

Claudia Gatta, Elena De Felice, Livia D'Angelo, Lucianna Maruccio, Adele Leggieri, Carla Lucini, Antonio Palladino, Marina Paolucci, Paola Scocco, Ettore Varricchio and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Assessing Bottlenose Dolphins' (Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Claudia GattaDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Elena De FeliceSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Livia D'AngeloDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Lucianna MaruccioDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Adele LeggieriDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Carla LuciniDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
Antonio PalladinoCenter for Advanced Biomaterials for Health Care, IIT@CRIB, Istituto Italiano di Tecnologia, Naples, Italy.
Marina PaolucciDepartment of Science and Technology, University of Sannio, Benevento, Italy.
Paola ScoccoSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Ettore VarricchioDepartment of Science and Technology, University of Sannio, Benevento, Italy.
Paolo de GirolamoDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · ITUniversità di Camerino · ITUniversity of Sannio · ITCenter for Advanced Biomaterials for Healthcare · ITStazione Zoologica Anton Dohrn · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nesfatin-1 (Nesf-1) is an anorexigenic peptide involved in the regulation of homeostatic feeding. Nesf-1 is expressed in the central nervous system and other organs, including pancreas, where it promotes the release of insulin from β-cells. This raises the possibility that Nesf-1 dysfunction could be involved in metabolic disorders, particularly in type 2 diabetes mellitus (T2D). Recently, it has been discovered that dolphins can be a natural animal model that fully replicates human T2D, due to its prolonged glucose tolerance curve and maintenance of a state of hyperglycemia similar to human T2D during fasting. This correspondence suggests that dolphins may be a suitable model for investigating physiological and pathological metabolic disorders. Here, we have characterized Nesf-1 distribution in the pancreas of the common bottlenose dolphin (

Indexed as

common bottlenose dolphinglycemic stateNesf-1pancreastype 2 diabetes mellitus

Identifiers

PMID30618845
PMCPMC6305742
OpenAlexW2903942456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.