Evidence map›Paper›PMID 30618837›Full record

ReviewFrontiers in physiology2018

Neural Control of Cardiovascular Function During Exercise in Hypertension.

Maryetta Dombrowski, Joseph Mannozzi, Donal S O'Leary

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maryetta DombrowskiDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, United States.
Joseph MannozziDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, United States.
Donal S O'LearyDepartment of Physiology and Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, United States.
Wayne State University · US

Funding

BLOOD PRESSURE CONTROL DURING EXERCISE IN HEART FAILURER01HL055473 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 1996 to 2024
$9.8M
Mechanisms Mediating Enhanced Sympatho-Activation During Exercise in HypertensionR01HL126706 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 2016 to 2019
$2.2M
NHLBI NIH HHS R01 HL055473NHLBI NIH HHS R01 HL126706
6 · The paper itself

Abstract

During both static and dynamic exercise hypertensive subjects can experience robust increases in arterial pressure to such an extent that heavy exercise is often not recommended in these patients due to the dangerously high levels of blood pressure sometimes observed. Currently, the mechanisms mediating this cardiovascular dysfunction during exercise in hypertension are not fully understood. The major reflexes thought to mediate the cardiovascular responses to exercise in normotensive healthy subjects are central command, arterial baroreflex and responses to stimulation of skeletal muscle mechano-sensitive and metabo-sensitive afferents. This review will summarize our current understanding of the roles of these reflexes and their interactions in mediating the altered cardiovascular responses to exercise observed in hypertension. We conclude that much work is needed to fully understand the mechanisms mediating excessive pressor response to exercise often seen in hypertensive patients.

Indexed as

arterial baroreflexcentral commanddynamic exerciseexercise pressor responsehypertension

Identifiers

PMID30618837
PMCPMC6306405
OpenAlexW2904297829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.