Evidence map›Paper›PMID 30618732›Full record

ArticleFrontiers in pharmacology2018

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain.

Amjad Khan, Tahir Ali, Shafiq Ur Rehman, Muhammad Sohail Khan, Sayed Ibrar Alam, Muhammad Ikram, Tahir Muhammad, Kamran Saeed, Haroon Badshah, Myeong Ok Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 4 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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  11. Astragaloside IV fromAntioxidants (Basel, Switzerland) · 2026
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Amjad KhanDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Tahir AliDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Shafiq Ur RehmanDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Muhammad Sohail KhanDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Sayed Ibrar AlamDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Muhammad IkramDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Tahir MuhammadDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Kamran SaeedDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Haroon BadshahDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Myeong Ok KimDivision of Applied Life Science (BK 21), College of Natural Science, Gyeongsang National University, Jinju, South Korea.
Gyeongsang National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide (LPS) is an essential component of the gram-negative bacterial cell wall and acts as a potent stimulator of neuroinflammation that mediates neurodegeneration. Quercetin is a natural flavonoid that is abundantly found in fruits and vegetables and has been shown to possess multiple forms of desirable biological activity including anti-inflammatory and antioxidant properties. This study aimed to evaluate the neuroprotective effect of quercetin against the detrimental effects of LPS, such as neuroinflammation-mediated neurodegeneration and synaptic/memory dysfunction, in adult mice. LPS [0.25 mg/kg/day, intraperitoneally (I.P.) injections for 1 week]-induced glial activation causes the secretion of cytokines/chemokines and other inflammatory mediators, which further activate the mitochondrial apoptotic pathway and neuronal degeneration. Compared to LPS alone, quercetin (30 mg/kg/day, I.P.) for 2 weeks (1 week prior to the LPS and 1 week cotreated with LPS) significantly reduced activated gliosis and various inflammatory markers and prevented neuroinflammation in the cortex and hippocampus of adult mice. Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain. The quercetin treatment significantly reversed the LPS-induced synaptic loss in the cortex and hippocampus of the adult mouse brain and improved the memory performance of the LPS-treated mice. In summary, our results demonstrate that natural flavonoids such as quercetin can be beneficial against LPS-induced neurotoxicity in adult mice.

Indexed as

activated gliosislipopolysaccharidememory performancenatural flavonoidsneuroinflammationneurotoxicityquercetin

Identifiers

PMID30618732
PMCPMC6297180
OpenAlexW2905148902

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.