ArticleFrontiers in aging neuroscience2018
Dissociable Effects of Aging on Salience Subnetwork Connectivity Mediate Age-Related Changes in Executive Function and Affect.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The neural underpinnings of intergroup social cognition: an fMRI meta-analysis.Social cognitive and affective neuroscience · 2021Pooled it
- Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.PLoS biology · 2026Article
- MJNMF-GAT: Multi-Task Joint Non-Negative Matrix Factorization Graph Attention Network for Understanding Adolescent Neurodevelopment.IEEE access : practical innovations, open solutions · 2025Article
- See no evil: Attentional bias toward threat is diminished in aged monkeys.Emotion (Washington, D.C.) · 2024Article
- Trajectories of brain entropy across lifetime estimated by resting state functional magnetic resonance imaging.Human brain mapping · 2022Article
- Brain Dynamics Underlying Cognitive Flexibility Across the Lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Neuroplasticity within and between Functional Brain Networks in Mental Training Based on Long-Term Meditation.Brain sciences · 2021Article
- Reorganization of brain structural networks in aging: A longitudinal study.Journal of neuroscience research · 2021Article
- Salience and default-mode network connectivity during threat and safety processing in older adults.Human brain mapping · 2021Article
- Affect in the Aging Brain: A Neuroimaging Meta-Analysis of Older Vs. Younger Adult Affective Experience and Perception.Affective science · 2020Article
- Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
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Authors and funding
5 authors.
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Abstract
Aging is associated with both changes in affective experience and attention. An intrinsic brain network subserving these functions, the salience network, has not shown clear evidence of a corresponding age-related change. We propose a solution to this discrepancy: that aging differentially affects the connectivity of two dissociated subsystems of the salience network identified in our prior research (Touroutoglou et al., 2012). We examined the age-related changes in intrinsic connectivity between a dorsal and a ventral salience subsystem in a sample of 111 participants ranging in age from 18 years to 81 years old. We predicted that connectivity within the ventral subsystem is relatively preserved with age, while connectivity in the dorsal subsystem declines. Our findings showed that the connectivity within the ventral subsystem was not only preserved but it actually increased with age, whereas the connectivity within the dorsal subsystem decreased with age. Furthermore, age-related increase in arousal experience was partially mediated by age-related increases in ventral salience subsystem, whereas age-related decline in executive function was fully mediated by age-related decreases in dorsal salience subsystem connectivity. These findings explain previously conflicting results on age-related changes in the salience network, and suggest a mechanism for relatively preserved affective function in the elderly.
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