ArticleFrontiers in aging neuroscience2018
Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Mapping Whole-Brain Nonlinear Structure-Function Dynamics in Aging via Neural Granger Causality.Brain topography · 2026Article
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- A cross-sectional and longitudinal study of changes in complex networks related to brain function in temporal lobe epilepsy patients treated with levetiracetam intervention therapy.Brain imaging and behavior · 2026Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.PLoS biology · 2026Article
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Structural connectome analysis using a graph-based deep model for prediction of non-imaging variables.Frontiers in neuroscience · 2026Article
- Topological turning points across the human lifespan.Nature communications · 2025Article
- Disrupted Structure-Function Integration in Systemic Lupus Erythematosus and Its Impact on Cognitive Flexibility.Human brain mapping · 2025Article
- Structural Connectome Analysis using a Graph-based Deep Model for Prediction of Non-Imaging Variables.bioRxiv : the preprint server for biology · 2025Article
- The Relationship Between the Phonological Processing Network and the Tip-of-the-Tongue Phenomenon: Evidence from Large-Scale DTI Data.Behavioral sciences (Basel, Switzerland) · 2025Article
- Amyloid pathology related to aberrant structure-function coupling of brain networks in Alzheimer's disease: insights from [European journal of nuclear medicine and molecular imaging · 2025Article
- Structural-functional brain network coupling during cognitive demand reveals intelligence-relevant communication strategies.Communications biology · 2025Article
- Graph Neural Network Learning on the Pediatric Structural Connectome.Tomography (Ann Arbor, Mich.) · 2025Article
- Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.Frontiers in neuroscience · 2025Article
- Structure-function coupling using fixel-based analysis and functional magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment.Network neuroscience (Cambridge, Mass.) · 2025Article
- Altered neurovascular coupling and structure-function coupling in Moyamoya disease affect postoperative collateral formation.Scientific reports · 2024Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
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13 authors.
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Abstract
According to the network-based neurodegeneration hypothesis, neurodegenerative diseases target specific large-scale neural networks, such as the default mode network, and may propagate along the structural and functional connections within and between these brain networks. Cognitive impairment no dementia (CIND) represents an early prodromal stage but few studies have examined brain topological changes within and between brain structural and functional networks. To this end, we studied the structural networks [diffusion magnetic resonance imaging (MRI)] and functional networks (task-free functional MRI) in CIND (61 mild, 56 moderate) and healthy older adults (97 controls). Structurally, compared with controls, moderate CIND had lower global efficiency, and lower nodal centrality and nodal efficiency in the thalamus, somatomotor network, and higher-order cognitive networks. Mild CIND only had higher nodal degree centrality in dorsal parietal regions. Functional differences were more subtle, with both CIND groups showing lower nodal centrality and efficiency in temporal and somatomotor regions. Importantly, CIND generally had higher structural-functional connectome correlation than controls. The higher structural-functional topological similarity was undesirable as higher correlation was associated with poorer verbal memory, executive function, and visuoconstruction. Our findings highlighted the distinct and progressive changes in brain structural-functional networks at the prodromal stage of neurodegenerative diseases.
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