Evidence map›Paper›PMID 30618710›Full record

ReviewFrontiers in aging neuroscience2018

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.

Ryan A Cloyd, Shon A Koren, Jose F Abisambra

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Contrast Agents for Enhanced Bioimaging: A Comprehensive Review.Chembiochem : a European journal of chemical biology · 2026
    Review
  5. Review
  6. ATP-responsive Mn(II)-basedChemical communications (Cambridge, England) · 2023
    Article
  7. Magnetic resonance imaging to assess the brain response to fasting in glioblastoma-bearing rats as a model of cancer anorexia.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. A Single-Pot Template Reaction Towards a Manganese-BasedAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  13. A Single-Pot Template Reaction Towards a Manganese-Based TAngewandte Chemie (International ed. in English) · 2021
    Article
  14. Article
  15. New Strategies in the Design of Paramagnetic CAs.Contrast media & molecular imaging · 2020
    Review
  16. Review
  17. Review
  18. Manganese-Enhanced MRI of the Brain in Healthy Volunteers.AJNR. American journal of neuroradiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryan A CloydDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Shon A KorenDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Jose F AbisambraDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
University of Kentucky · US

Funding

University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Protein CoreP30GM110787 · NIGMS · UNIVERSITY OF KENTUCKY · PI WHITEHEART, SIDNEY WALDO · 2014 to 2018
$5.7M
NRSA Training CoreTL1TR001997 · NCATS · UNIVERSITY OF KENTUCKY · PI PENDERGAST, JULIE S, STOOPS, WILLIAM WALTON · 2016 to 2025
$4.2M
PERK as a Central Mediator of Neurotoxicity in TauopathiesR01NS091329 · NINDS · UNIVERSITY OF KENTUCKY · PI ABISAMBRA, JOSE FRANCISCO · 2015 to 2019
$1.6M
NCATS NIH HHS TL1 TR001997NCATS NIH HHS UL1 TR000117NIA NIH HHS P30 AG028383NIGMS NIH HHS P30 GM110787NIMHD NIH HHS L32 MD009205NINDS NIH HHS R01 NS091329
6 · The paper itself

Abstract

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current

Indexed as

CNS imagingmangafodipirmanganeseMEMRIMRI

Identifiers

PMID30618710
PMCPMC6300587
OpenAlexW2905545839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.