ArticleFrontiers in computational neuroscience2018
Suppression of Parkinsonian Beta Oscillations by Deep Brain Stimulation: Determination of Effective Protocols.
Article in Frontiers in computational neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Cognitive outcomes of deep brain stimulation depend on age and hippocampal connectivity in Parkinson's and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Unlocking potential: low frequency subthalamic nucleus stimulation enhances executive function in Parkinson's disease patients with postural instability/gait disturbance.Frontiers in neuroscience · 2023Article
- The Effects of Subthalamic Nucleus Deep Brain Stimulation and Retention Delay on Memory-Guided Reaching Performance in People with Parkinson's Disease.Journal of Parkinson's disease · 2023Article
- The effect of age and disease duration on the efficacy of subthalamic nuclei deep brain stimulation in Parkinson's disease patients.CNS neuroscience & therapeutics · 2022Article
- Developments in Deep Brain Stimulators for Successful Aging Towards Smart Devices-An Overview.Frontiers in aging · 2022Review
- Article
- Encoding type, medication, and deep brain stimulation differentially affect memory-guided sequential reaching movements in Parkinson's disease.Frontiers in neurology · 2022Article
- Dopaminergic Modulation of Local Non-oscillatory Activity and Global-Network Properties in Parkinson's Disease: An EEG Study.Frontiers in aging neuroscience · 2022Article
- Bifurcation analyses and potential landscapes of a cortex-basal ganglia-thalamus model.IET systems biology · 2021Article
- Gamma Oscillations and Coherence Are Weaker in the Dorsomedial Subregion of STN in Parkinson's Disease.Frontiers in neurology · 2021Article
- The effect of STN DBS on modulating brain oscillations: consequences for motor and cognitive behavior.Experimental brain research · 2020Review
- Evolving concepts on bradykinesia.Brain : a journal of neurology · 2020Review
- A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation.Frontiers in neurology · 2020Article
- A Population Model of Deep Brain Stimulation in Movement Disorders From Circuits to Cells.Frontiers in human neuroscience · 2020Article
- Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients.Frontiers in human neuroscience · 2020Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A neural field model of the corticothalamic-basal ganglia system is developed that describes enhanced beta activity within subthalamic and pallidal circuits in Parkinson's disease (PD) via system resonances. A model of deep brain stimulation (DBS) of typical clinical targets, the subthalamic nucleus (STN) and globus pallidus internus (GPi), is added and studied for several distinct stimulation protocols that are used for treatment of the motor symptoms of PD and that reduce pathological beta band activity (13-30 Hz) in the corticothalamic-basal ganglia network. The resulting impact of DBS on enhanced beta activity in the STN and GPi, as well as cortico-subthalamic and cortico-pallidal coherence, are studied. Both STN-DBS and GPi-DBS are found to be effective for suppressing peak STN and GPi power in the beta band, with GPi-DBS being slightly more effective in both the STN and the GPi for all stimulus protocols tested. The largest decrease in cortico-STN coherence is observed during STN-DBS, whereas GPi-DBS is most effective for reducing cortico-GPi coherence. A reduction of the pathologically large STN connection strengths that define the parkinsonian state results in enhanced 6 Hz activity and could thus represent a compensatory mechanism that has the side effect of driving parkinsonian tremor-like oscillations. This model provides a method for systematically testing effective DBS protocols that agrees with experimental and clinical findings. Furthermore, the model suggests GPi-DBS and STN-DBS have distinct impacts on elevated synchronization between the basal ganglia and motor cortex in PD.
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