Evidence map›Paper›PMID 30618607›Full record

ReviewFrontiers in molecular neuroscience2018

microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease.

Kristen T Thomas, Christina Gross, Gary J Bassell

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  18. Role and Dysregulation of miRNA in Patients with Parkinson's Disease.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kristen T ThomasDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Christina GrossDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Gary J BassellDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · USSt. Jude Children's Research Hospital · USUniversity of Cincinnati Medical Center · US

Funding

Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
FMRP Mechanism and FunctionR01MH109026 · NIMH · EMORY UNIVERSITY · PI BASSELL, GARY J · 2016 to 2020
$2.0M
MicroRNA-mediated silencing of the Kv4.2 complex in epilepsyR01NS092705 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI GROSS, CHRISTINA · 2016 to 2020
$1.8M
Regulation of dendritic Kv4.2 expression by neuronal microRNAsF31NS087713 · NINDS · EMORY UNIVERSITY · PI THOMAS, KRISTEN THERESE · 2014 to 2016
$129k
NIMH NIH HHS R01 MH109026NINDS NIH HHS F31 NS087713NINDS NIH HHS R01 NS092705NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Since the discovery of the first microRNA 25 years ago, microRNAs (miRNAs) have emerged as critical regulators of gene expression within the mammalian brain. miRNAs are small non-coding RNAs that direct the RNA induced silencing complex to complementary sites on mRNA targets, leading to translational repression and/or mRNA degradation. Within the brain, intra- and extracellular signaling events tune the levels and activities of miRNAs to suit the needs of individual neurons under changing cellular contexts. Conversely, miRNAs shape neuronal communication by regulating the synthesis of proteins that mediate synaptic transmission and other forms of neuronal signaling. Several miRNAs have been shown to be critical for brain function regulating, for example, enduring forms of synaptic plasticity and dendritic morphology. Deficits in miRNA biogenesis have been linked to neurological deficits in humans, and widespread changes in miRNA levels occur in epilepsy, traumatic brain injury, and in response to less dramatic brain insults in rodent models. Manipulation of certain miRNAs can also alter the representation and progression of some of these disorders in rodent models. Recently, microdeletions encompassing

Indexed as

BDNFepilepsymicroRNAmiR-137miRNA biogenesisneuronal signal transductionNrg1schizophrenia

Identifiers

PMID30618607
PMCPMC6299112
OpenAlexW2904270425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.