Evidence map›Paper›PMID 30618589›Full record

ArticleFrontiers in neuroscience2018

Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2.

Zhimin Xu, Abdelrahman Y Fouda, Tahira Lemtalsi, Esraa Shosha, Modesto Rojas, Fang Liu, Chintan Patel, R William Caldwell, Subhadra Priya Narayanan, Ruth B Caldwell

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  4. Dual role of complement in neuronal repair.Frontiers in immunology · 2025
    Review
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  20. NOD-like Receptors in the Eye: Uncovering Its Role in Diabetic Retinopathy.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zhimin XuCharlie Norwood VA Medical Center, Augusta, GA, United States.
Abdelrahman Y FoudaCharlie Norwood VA Medical Center, Augusta, GA, United States.
Tahira LemtalsiCharlie Norwood VA Medical Center, Augusta, GA, United States.
Esraa ShoshaCharlie Norwood VA Medical Center, Augusta, GA, United States.
Modesto RojasCharlie Norwood VA Medical Center, Augusta, GA, United States.
Fang LiuCharlie Norwood VA Medical Center, Augusta, GA, United States.
Chintan PatelVascular Biology Center, Augusta University, Augusta, GA, United States.
R William CaldwellJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, United States.
Subhadra Priya NarayananCharlie Norwood VA Medical Center, Augusta, GA, United States.
Ruth B CaldwellCharlie Norwood VA Medical Center, Augusta, GA, United States.
Augusta University · USGeorgia College & State University · USAugusta University Health · US

Funding

Cellular Mechanisms of Retinopathy: Role of ArginaseR01EY011766 · NEI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI CALDWELL, ROBERT WILLIAM, CALDWELL, RUTH B · 1998 to 2021
$6.7M
Mechanisms of Diabetic Retinopathy: Oxidative Stress and InflammationI01BX001233 · VA · CHARLIE NORWOOD VA MEDICAL CENTER · PI CALDWELL, RUTH B · 2012 to 2015
–
American Heart Association-American Stroke Association 18POST34060036BLRD VA I01 BX001233NEI NIH HHS R01 EY011766
6 · The paper itself

Abstract

Our previous studies have implicated expression of the mitochondrial isoform of the arginase enzyme arginase 2 (A2) in neurovascular injury during ischemic retinopathies. The aim of this study was to characterize the specific involvement of A2 in retinal injury following optic nerve crush (ONC). To accomplish this, wild-type (WT) or A2 knockout (A2

Indexed as

arginase 2brain derived neurotrophic factorneuroprotectionoptic nerve crushretinaretinal ganglion cells

Identifiers

PMID30618589
PMCPMC6306467
OpenAlexW2905969400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.