Evidence map›Paper›PMID 30618582›Full record

ArticleFrontiers in neuroscience2018

Improving Sparsity and Modularity of High-Order Functional Connectivity Networks for MCI and ASD Identification.

Yueying Zhou, Limei Zhang, Shenghua Teng, Lishan Qiao, Dinggang Shen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Yueying ZhouSchool of Mathematics Science, Liaocheng University, Liaocheng, China.
Limei ZhangSchool of Mathematics Science, Liaocheng University, Liaocheng, China.
Shenghua TengCollege of Electronic and Information Engineering, Shandong University of Science and Technology, Qingdao, China.
Lishan QiaoSchool of Mathematics Science, Liaocheng University, Liaocheng, China.
Dinggang ShenDepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Liaocheng University · CNShandong University of Science and Technology · CNUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-order correlation has recently been proposed to model brain functional connectivity network (FCN) for identifying neurological disorders, such as mild cognitive impairment (MCI) and autism spectrum disorder (ASD). In practice, the high-order FCN (HoFCN) can be derived from multiple low-order FCNs that are estimated separately in a series of sliding windows, and thus it in fact provides a way of integrating dynamic information encoded in a sequence of low-order FCNs. However, the estimation of low-order FCN may be unreliable due to the fact that the use of limited volumes/samples in a sliding window can significantly reduce the statistical power, which in turn affects the reliability of the resulted HoFCN. To address this issue, we propose to enhance HoFCN based on a regularized learning framework. More specifically, we first calculate an initial HoFCN using a recently developed method based on maximum likelihood estimation. Then, we learn an optimal neighborhood network of the initially estimated HoFCN with sparsity and modularity priors as regularizers. Finally, based on the improved HoFCNs, we conduct experiments to identify MCI and ASD patients from their corresponding normal controls. Experimental results show that the proposed methods outperform the baseline methods, and the improved HoFCNs with modularity prior consistently achieve the best performance.

Indexed as

autism spectrum disorderdynamic networkfunctional connectivity networkhigh-order correlationmild cognitive impairmentmodularity

Identifiers

PMID30618582
PMCPMC6305547
OpenAlexW2905545847

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.