Evidence map›Paper›PMID 30618556›Full record

ArticleFrontiers in neuroscience2018

Alterations of Graphic Properties and Related Cognitive Functioning Changes in Mild Alzheimer's Disease Revealed by Individual Morphological Brain Network.

Wan Li, Chunlan Yang, Shuicai Wu, Yingnan Nie, Xin Zhang, Ming Lu, Tongpeng Chu, Feng Shi

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wan LiCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Chunlan YangCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Shuicai WuCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Yingnan NieCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Xin ZhangCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Ming LuCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Tongpeng ChuCollege of Life Science and Bioengineering, Beijing University of Technology, Beijing, China.
Feng ShiDepartment of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is one of the most common forms of dementia that has slowly negative impacts on memory and cognition. With the assistance of multimodal brain networks and graph-based analysis approaches, AD-related network disruptions support the hypothesis that AD can be identified as a dysconnectivity syndrome. However, as the recent emerging of individual-based morphological network research of AD, the utilization of multiple morphometric features may provide a broader horizon for locating the lesions. Therefore, the present study applied the newly proposed individual morphological brain network with five commonly used morphometric features (cortical thickness, regional volume, surface area, mean curvature, and fold index) to explore the topological aberrations and their relationship with cognitive functioning alterations in the early stage of AD. A total of 40 right-handed participants were selected from Open Access Series of Imaging Studies Database with 20 AD patients (age ranged from 70 to 79, CDR = 0.5) and 20 age/gender-matched healthy controls. The significantly affected connections (

Indexed as

Alzheimer’s diseasecognitive functioninggraph theoryindividual morphological brain networksmultiple morphometric features

Identifiers

PMID30618556
PMCPMC6295573

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.