ArticleFrontiers in neuroscience2018
Neuropeptides SP and CGRP Underlie the Electrical Properties of Acupoints.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Acupoint Sensitivity in Health and Disease: A Systematic Review.Journal of integrative and complementary medicine · 2024Pooled it
- CHRNA3⁺ nociceptors prime the cutaneous sensory interface to enhance electroacupuncture analgesia.Chinese medicine · 2026Article
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
- Portable devices for periodic monitoring of bioelectrical impedance along meridian pathways in healthy individuals.Biomedical engineering online · 2025Article
- Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway.Genes & genomics · 2025Article
- Article
- Ginger Moxibustion Activates TRPV1 to Modulate the Locus Coeruleus-Spinal Cord-Uterus Pathway and Alleviates Primary Dysmenorrhea in Rats.Journal of pain research · 2025Article
- Exploratory Study of Biomechanical Properties and Pain Sensitivity at Back-Shu Points.Brain sciences · 2024Article
- Deep electroacupuncture of neurogenic spots attenuates immobilization stress-induced acute hypertension in rats.Integrative medicine research · 2024Article
- Stimuli-induced NOergic Molecules and Neuropeptides Mediated Axon Reflexes Contribute to Tracers along Meridian Pathways.Current topics in medicinal chemistry · 2024Review
- Sympathetic-Sensory Coupling as a Potential Mechanism for Acupoints Sensitization.Journal of pain research · 2023Review
- Attenuation of immobilization stress-induced hypertension by temperature-controllable warm needle acupuncture in rats and the peripheral neural mechanisms.Frontiers in neurology · 2023Article
- Acupuncture Enhances Signals at Sensitized Acupoints to Elevate Pressure Pain Threshold in Knee Osteoarthritis Patients.Chinese journal of integrative medicine · 2022Article
- Shared nociceptive dorsal root ganglion neurons participating in acupoint sensitization.Frontiers in molecular neuroscience · 2022Article
- Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors.Frontiers in neuroscience · 2022Review
- Electroacupuncture Treats Myocardial Infarction by Influencing the Regulation of Substance P in the Neurovascular to Modulate PGI2/TXA2 Metabolic Homeostasis via PI3K/AKT Pathway: A Bioinformatics-Based Multiomics and Experimental Study.Computational and mathematical methods in medicine · 2022Article
- Low Electrical Resistance Properties of Acupoints: Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance.Chinese journal of integrative medicine · 2021Article
- Electroacupuncture at Neurogenic Spots in Referred Pain Areas Attenuates Hepatic Damages in Bile Duct-Ligated Rats.International journal of molecular sciences · 2021Article
- The role of substance P in acupuncture signal transduction and effects.Brain, behavior, and immunity · 2021Article
- Meridian study on the response current affected by electrical pulse and acupuncture.Nanoscale research letters · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical skin measurements at acupuncture points (acupoints) have been utilized as a diagnostic and therapeutic aid for more than 50 years. Although acupoints are described as having distinct electrical properties, such as high conductance and low impedance, the underlying mechanisms are currently unknown. The present study investigated in a rat model of hypertension whether the high conductance at acupoints is a result of the release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) during neurogenic inflammation in the referred pain area. When plasma extravasation from neurogenic inflammation was examined by exploring the leakage of intravenously injected Evans blue dye (EBD) to the skin, extravasated EBD was found most frequently in acupoints on the wrist. The increased conductance and temperature at these acupoints occurred during the development of hypertension. The increase in conductance and plasma extravasation at acupoints in hypertensive rats was ablated by cutting median and ulnar nerves, blocking small diameter afferent fibers with resiniferatoxin (RTX) injection into median and ulnar nerves, or antagonizing SP or CGRP receptors in acupoints. In turn, intradermal injection of SP or CGRP resulted in increased conductance and plasma extravasation in naïve rats. Elevated levels of SP and CGRP were found in the acupoints of hypertensive rats. These findings suggest that the high conductance at acupoints is due to vascular leakage following local release of SP and CGRP during neurogenic inflammation.
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