ArticleJournal of Korean medical science2019
The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction.
Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04514146 (A Pilot Study on the Effects of Water-only Fasting and Refeeding on Body Composition and Insulin Resistance), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study on the Effects of Water-only Fasting and Refeeding on Body Composition and Insulin Resistance
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Association between visceral adiposity index and risk of prediabetes: A meta-analysis of observational studies.Journal of diabetes investigation · 2022Pooled it
- Trial
- Cardiometabolic health, visceral fat and circulating irisin levels: results from a real-world weight loss study.Journal of endocrinological investigation · 2021Trial
- Recent advances in methotrexate pharmacology and potential therapeutic uses in age-related cardiometabolic and neurodegenerative diseases.Pharmacological reviews · 2026Review
- Obesity and female reproductive health in Asian population.Obesity pillars · 2026Review
- FTO in cardiovascular diseases: mechanisms, context dependence, and translational opportunities.Frontiers in cell and developmental biology · 2026Review
- Interplay Between Enteroendocrine Hormone (Leptin) and Adipokines (Ghrelin and Adiponectin) with Gastric Expression of FTO and MC4R Genes.Scientific reports · 2025Article
- Impaired Glucose Tolerance and Altered Body Composition in Obese Young Adults: A Case-Control Study.Biomedicines · 2025Article
- A Body Shape Index (ABSI) as a risk factor for all-cause mortality among US adults with type 2 diabetes: evidence from the NHANES 1999-2018.Journal of diabetes and metabolic disorders · 2025Article
- Clinical characteristics of lean and non-lean non-alcoholic fatty liver disease: a cross-sectional study.Nutrition & metabolism · 2025Article
- Anthropometric and metabolic parameters associated with visceral fat in non-obese type 2 diabetes individuals.Diabetology & metabolic syndrome · 2025Article
- Metabolic and inflammatory status in prepuberty and early adulthood for individuals with a history of extrauterine growth restriction: a cohort study.Journal of translational medicine · 2025Article
- The Role of Diet, Glycaemic Index and Glucose Control in Polycystic Ovary Syndrome (PCOS) Management and Mechanisms of Progression.Current nutrition reports · 2025Review
- Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes.Cardiovascular diabetology · 2025Article
- U-Shaped Association of Visceral Fat Area With Diabetic Peripheral Neuropathy.Journal of diabetes research · 2025Article
- Relationship between body roundness index and mortality rates and life expectancy in populations with metabolic syndrome.Frontiers in cardiovascular medicine · 2025Article
- The non-linear relationship between the visceral adiposity index and the risk of prediabetes and diabetes.Frontiers in endocrinology · 2025Article
- Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction.Nutrients · 2024Article
- Exploring the Interplay between Vitamin D, Insulin Resistance, Obesity and Skeletal Health.Journal of bone metabolism · 2024Article
- Hyperactive behaviour of growth differentiation factor- 15 (GDF-15) in conjunction with iron trafficking transporters and suppression of Nrf-2 gene in diabetes and metabolic syndrome.Molecular and cellular biochemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a risk factor for metabolic abnormalities. We investigated the relationship of adiponectin levels and visceral adiposity with insulin resistance and β-cell dysfunction.
methodsThis cross-sectional study enrolled 1,347 participants (501 men and 846 women aged 30-64 years) at the Cardiovascular and Metabolic Diseases Etiology Research Center. Serum adiponectin levels and visceral fat were measured using enzyme-linked immunosorbent assay kits and dual-energy X-ray absorptiometry, respectively. Insulin resistance was evaluated using the homeostatic model assessment of insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index. β-cell dysfunction was evaluated using the homeostatic model assessment of β-cell function (HOMA-β), insulinogenic index, and disposition index.
resultsRegarding insulin resistance, compared with individuals with the highest adiponectin levels and visceral fat mass < 75th percentile, the fully adjusted odds ratios (ORs) for HOMA-IR ≥ 2.5 and Matsuda index < 25th percentile were 13.79 (95% confidence interval, 7.65-24.83) and 8.34 (4.66-14.93), respectively, for individuals with the lowest adiponectin levels and visceral fat ≥ 75th percentile. Regarding β-cell dysfunction, the corresponding ORs for HOMA-β < 25th percentile, insulinogenic index < 25th percentile, and disposition index < 25th percentile were 1.20 (0.71-2.02), 1.01 (0.61-1.66), and 1.87 (1.15-3.04), respectively.
conclusionLow adiponectin levels and high visceral adiposity might affect insulin resistance and β-cell dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.