ArticleJournal of clinical neurology (Seoul, Korea)2019
Pivotal Role of Subcortical Structures as a Network Hub in Focal Epilepsy: Evidence from Graph Theoretical Analysis Based on Diffusion-Tensor Imaging.
Article in Journal of clinical neurology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Altered Brain Functional Connectivity in Postherpetic Neuralgia and Its Association With Neuropathic Pain.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.Brain topography · 2026Article
- High-Density Electroencephalography Detects Spatiotemporal Abnormalities in Brain Networks in Patients With Glioma-Related Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Subcortical Alterations in Newly Diagnosed Epilepsy and Associated Changes in Brain Connectivity and Cognition.Human brain mapping · 2024Review
- Functional Connectivity Alterations in Patients with Post-stroke Epilepsy Based on Source-level EEG and Graph Theory.Brain topography · 2024Article
- Alterations of apparent diffusion coefficient from ultra high b-values in the bilateral thalamus and striatum in MRI-negative drug-resistant epilepsy.Epilepsia open · 2024Article
- Cerebellar volumes and the intrinsic cerebellar network in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Effect of glymphatic system function on cognitive function in patients with chronic kidney disease.Frontiers in neurology · 2024Article
- A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network.Brain structure & function · 2023Article
- Predicting Sumatriptan Responsiveness Based on Structural Connectivity in Patients Newly Diagnosed With Migraine.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Quantitative susceptibility mapping identifies hippocampal and other subcortical grey matter tissue composition changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- Brain networks and epilepsy development in patients with Alzheimer disease.Brain and behavior · 2023Article
- Structural brain network analysis in occipital lobe epilepsy.BMC neurology · 2023Article
- Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging.Brain and behavior · 2023Article
- Thalamic nuclei volumes and intrinsic thalamic network in patients with occipital lobe epilepsy.Brain and behavior · 2023Article
- Involvement of limbic structures in patients with isolated rapid eye movement sleep behavior disorder.Sleep and biological rhythms · 2023Article
- Brain diffusion tensor imaging reveals altered connections and networks in epilepsy patients.Frontiers in human neuroscience · 2023Article
- Alterations of thalamic nuclei volumes in patients with cluster headache.Neuroradiology · 2022Article
- Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI.Frontiers in neuroscience · 2022Article
- Characterization of Hippocampal-Thalamic-Cortical Morphometric Reorganization in Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
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7 authors.
Funding
Abstract
background and purposeThere is accumulating evidence that epilepsy is caused by network dysfunction. We evaluated the hub reorganization of subcortical structures in patients with focal epilepsy using graph theoretical analysis based on diffusion-tensor imaging (DTI). In addition, we investigated differences in the values of diffusion tensors and scalars, fractional anisotropy (FA), and mean diffusivity (MD) of subcortical structures between patients with focal epilepsy and healthy subjects.
methodsOne hundred patients with focal epilepsy and normal magnetic resonance imaging (MRI) findings and 80 age- and sex-matched healthy subjects were recruited prospectively. All subjects underwent DTI to obtain data suitable for graph theoretical analysis. We investigated the differences in the node strength, cluster coefficient, eigenvector centrality, page-rank centrality measures, FA, and MD of subcortical structures between patients with epilepsy and healthy subjects.
resultsAfter performing multiple corrections, the cluster coefficient and the eigenvector centrality of the globus pallidus were higher in patients with epilepsy than in healthy subjects (
conclusionsWe discovered the presence of hub reorganization of subcortical structures in focal epilepsy patients with normal MRI findings, suggesting that subcortical structures play a pivotal role as a hub in the epilepsy network. These findings further reinforce the idea that epilepsy is a network disease.
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