ArticleJournal of clinical neurology (Seoul, Korea)2019
White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China.
Article in Journal of clinical neurology (Seoul, Korea), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Imaging markers of cerebral small vessel disease are associated with Alzheimer's disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Bioactive Compounds of Aboveground OrgansMolecules (Basel, Switzerland) · 2026Article
- Independent Role of White Matter Hyperintensity Volume and Location in Alzheimer's Disease Risk Beyond Hippocampal Atrophy.Psychiatry investigation · 2025Article
- Cerebral white matter damage in patients with end-stage kidney disease associates with cognitive impairment.Clinical kidney journal · 2025Article
- Different associations between body mass index and Alzheimer's markers depending on metabolic health.Alzheimer's research & therapy · 2024Article
- Contributions of amyloid beta and cerebral small vessel disease in clinical decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Independent effect of Aβ burden on cognitive impairment in patients with small subcortical infarction.Alzheimer's research & therapy · 2023Article
- Progression of cerebral white matter hyperintensities is related to leucocyte gene expression.Brain : a journal of neurology · 2022Article
- [Association between Cerebral Small Vessel and Alzheimer's Disease].Taehan Yongsang Uihakhoe chi · 2022Review
- Higher Comorbidity Burden Predicts Worsening Neurocognitive Trajectories in People with Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Cerebral perfusion and the risk of cognitive decline and dementia in community dwelling older people.Cerebral circulation - cognition and behavior · 2022Article
- Association of Cerebral Small Vessel Disease With Gait and Balance Disorders.Frontiers in aging neuroscience · 2022Review
- Electrochemically inducedFrontiers in cell and developmental biology · 2022Article
- Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case-Control Study.Frontiers in aging neuroscience · 2021Article
- Cerebral Small Vessel Disease and Alzheimer's Disease: A Review.Frontiers in neurology · 2020 · on this mapReview
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeThis study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an elderly cohort in China.
methodsOlder adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale.
resultsAmong the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI.
conclusionsHaving moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.