Evidence map›Paper›PMID 30618122›Full record

ArticleJournal of cellular and molecular medicine2019

MicroRNAs mediate liver transcriptome changes upon soy diet intervention in mice.

Edward Seclaman, Loredana Balacescu, Ovidiu Balacescu, Cristina Bejinar, Mihai Udrescu, Catalin Marian, Ioan Ovidiu Sirbu, Andrei Anghel

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Edward SeclamanDepartment of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.
Loredana BalacescuDepartment of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.
Ovidiu BalacescuDepartment of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.
Cristina BejinarDepartment of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.
Mihai UdrescuDepartment of Computer and Information Technology, Politehnica University of Timisoara, Timisoara, Romania.
Catalin MarianDepartment of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.
Ioan Ovidiu SirbuDepartment of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.ORCID 0000-0003-1618-9656
Andrei AnghelDepartment of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.
Victor Babeș University of Medicine and Pharmacy Timișoara · ROInstitute of Oncology Prof. Dr. Ion Chiricuta · ROPolytechnic University of Timişoara · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soy-based diets have triggered the interest of the research community due to their beneficial effects on a wide variety of pathologies like breast and prostate cancer, diabetes and atherosclerosis. However, the molecular details underlying these effects are far from being completely understood; several recent attempts have been made to elucidate the soy-induced liver transcriptome changes in different animal models. Here we used Next Generation Sequencing to identify a set of microRNAs specifically modulated by short-term soy-enriched diet in young male mice and estimated their impact on the liver transcriptome assessed by microarray. Clustering and topological community detection (CTCD) network analysis of STRING generated interactions of transcriptome data led to the identification of four topological communities of genes characteristically altered and putatively targeted by microRNAs upon soy diet intervention.

Indexed as

DietSoy FoodsAnimalsCluster AnalysisGene Regulatory NetworksHigh-Throughput Nucleotide SequencingLiverMaleMiceMicroRNAsRNA, MessengerTranscriptomeMicroRNAsRNA, Messenger

Identifiers

PMID30618122
PMCPMC6378209
OpenAlexW2909420321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.