Evidence map›Paper›PMID 30617987›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.

Kevin B Chiu, Kim M Lee, Katelyn N Robillard, Andrew G MacLean

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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  10. Culture Model for Non-human Primate Choroid Plexus.Frontiers in cellular neuroscience · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kevin B ChiuTulane National Primate Research Center, Covington, LA, USA.
Kim M LeeTulane National Primate Research Center, Covington, LA, USA.
Katelyn N RobillardTulane National Primate Research Center, Covington, LA, USA.
Andrew G MacLeanTulane National Primate Research Center, Covington, LA, USA. amaclean@tulane.edu.
Tulane University · USLouisiana State University Health Sciences Center New Orleans · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
ZCM:A NOVEL BROAD-SPECTRUM MICROBICIDE FOR SEXUALLY TRANSMITTED INFECTIONSP51RR000164 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI VEAZEY, RONALD S. · 1985 to 2011
$100.1M
Eradication of latent SIV from the CNSR01NS104016 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI LING, BINHUA "JULIE", MACLEAN, ANDREW G · 2017 to 2021
$3.7M
Exosome Origin in HIV PathogenesisR21MH113517 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI MACLEAN, ANDREW G · 2017 to 2018
$470k
NCRR NIH HHS P51 RR000164NIH HHS P51 OD011104NIMH NIH HHS R21 MH113517NINDS NIH HHS R01 NS104016
6 · The paper itself

Abstract

With a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. Using the unique archive at the Tulane National Primate Research Center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. This method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner.

Indexed as

AgingAnimalsAstrocytesBiomarkersBrainDNA-Binding ProteinsGlial Fibrillary Acidic ProteinImage Processing, Computer-AssistedImmunohistochemistryMacaca mulattaMicrogliaSoftwareBiomarkersDNA-Binding ProteinsGlial Fibrillary Acidic ProteinAgingAstrocyteEugericMicrogliaNeurodegenerationNeuroinflammation

Identifiers

PMID30617987
PMCPMC6428051
OpenAlexW2908935103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.