ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2019
Impact of Insulin Injection and Infusion Routines on Lipohypertrophy and Glycemic Control in Children and Adults with Diabetes.
Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Cutaneous Adverse Effects From Diabetes Devices in Pediatric Patients With Type 1 Diabetes Mellitus: Systematic Review.JMIR dermatology · 2024Pooled it
- The Economic Burden of Insulin Injection-Induced Lipohypertophy. Role of Education: The ISTERP-3 Study.Advances in therapy · 2022Trial
- Continuous Subcutaneous Levodopa Delivery for Parkinson's Disease: A Randomized Study.Journal of Parkinson's disease · 2021Trial
- Lipodystrophy and associated factors among patients with diabetes receiving insulin therapy: a multicenter study in Ethiopia.Scientific reports · 2026Article
- Lipodystrophy With an Uncommon Clinical Presentation in a Patient With Insulin-Requiring Type 2 Diabetes Mellitus.Cureus · 2024Article
- Efficacy of Sound Touch Elastography in Assessing Subcutaneous Lipohypertrophy from Insulin Injections.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Exploring the Diagnostic Value of High-Frequency Ultrasound Technology for Subcutaneous Lipohypertrophy in Diabetes Patients Receiving Insulin Injections.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center.Acta bio-medica : Atenei Parmensis · 2023Article
- Investigation of Association Between Insulin Injection Technique and Blood Glucose Control in Patients with Type 2 Diabetes.International journal of endocrinology and metabolism · 2022Article
- The Impact of Insulin-Induced Lipodystrophy on Glycemic Variability in Pediatric Patients with Type 1 Diabetes.Children (Basel, Switzerland) · 2022Article
- Clinical Implementation of the Omnipod 5 Automated Insulin Delivery System: Key Considerations for Training and Onboarding People With Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2022Article
- Insulin-induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump.International journal of endocrinology · 2022Article
- Characteristics and morphology of lipohypertrophic lesions in adults with type 1 diabetes with ultrasound screening: an exploratory observational study.BMJ open diabetes research & care · 2021Observational
- Subcutaneous Levodopa Infusion for Parkinson's Disease: 1-Year Data from the Open-Label BeyoND Study.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Phenolic Preservative Removal from Commercial Insulin Formulations Reduces Tissue Inflammation while Maintaining Euglycemia.ACS pharmacology & translational science · 2021Article
- A Systematic Survey of Physicians' Insights Into Lipohypertrophy.Frontiers in public health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionProper insulin injection/infusion is essential to optimize insulin absorption and action. Guidelines on insulin injection techniques are available. Lipohypertrophy (LH) is a local complication of insulin therapy, which results in erratic absorption and impaired glycemic control.
methodsChildren and adults with type 1 diabetes on insulin injection or infusion were enrolled in the study. Subjects were interviewed and filled in a questionnaire on injection/infusion routines. Sites of injection/infusion were examined by trained diabetes educators, and capillary HbA1c was obtained.
resultsOne hundred sixty-nine subjects (104 children) with type 1 diabetes were enrolled; 119 were on multiple daily injection (MDI) and 50 on insulin pump therapy. Seventy-two percent and 82% of children and adults, respectively, rotate site at every injection; 78% of pump users change infusion set and 74% rotate site at 2-3 days. Thirty-nine percent and 32% of children and adults had LH. HbA1c was lower in children and adults with no LH (P < 0.001). An association was seen between LH and rotation frequency in children (P = 0.026). LH was the most common skin complication in the MDI group, while nodules, allergy marks and hyperpigmentation were seen in pump users.
conclusionProper injection/infusion routines impact glycemic control and skin health. Education and examination of injection sites remain a crucial part of diabetes management.
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