ArticleBrain imaging and behavior2020
Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Longitudinal spatial changes of the contralesional corticospinal tract in high-grade glioma: a within-patient DTI tractography study.Journal of neuro-oncology · 2026Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Predictive value of deformity angular ratio (DAR) for intraoperative neuromonitoring (IONM) signal loss and neurological complications in spinal deformity surgery: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Lifespan Trajectories of Asymmetry in White Matter Tracts.bioRxiv : the preprint server for biology · 2025Article
- Circuits and mechanisms for TMS-induced corticospinal waves: Connecting sensitivity analysis to the network graph.PLoS computational biology · 2024Article
- Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods.Human brain mapping · 2023Article
- Extra-axonal contribution to double diffusion encoding-based pore size estimates in the corticospinal tract.Magma (New York, N.Y.) · 2023Article
- Usefulness and Limits of Tractography for Surgery in the Precentral Gyrus-A Case Report.Clinics and practice · 2022Article
- Morphologic Variants of the Hand Motor Cortex in Developing Brains from Neonates through Childhood Assessed by MR Imaging.AJNR. American journal of neuroradiology · 2022Article
- Anatomically curated segmentation of human subcortical structures in high resolution magnetic resonance imaging: An open science approach.Frontiers in neuroanatomy · 2022Article
- HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex.Frontiers in neuroanatomy · 2022Article
- The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches.Neural regeneration research · 2021Article
- Tractography-Based Analysis of Morphological and Anatomical Characteristics of the Uncinate Fasciculus in Human Brains.Brain sciences · 2020Article
- Cognitive and White-Matter Compartment Models Reveal Selective Relations between Corticospinal Tract Microstructure and Simple Reaction Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
The corticospinal tract (CST) is one of the most well studied tracts in human neuroanatomy. Its clinical significance can be demonstrated in many notable traumatic conditions and diseases such as stroke, spinal cord injury (SCI) or amyotrophic lateral sclerosis (ALS). With the advent of diffusion MRI and tractography the computational representation of the human CST in a 3D model became available. However, the representation of the entire CST and, specifically, the hand motor area has remained elusive. In this paper we propose a novel method, using manually drawn ROIs based on robustly identifiable neuroanatomic structures to delineate the entire CST and isolate its hand motor representation as well as to estimate their variability and generate a database of their volume, length and biophysical parameters. Using 37 healthy human subjects we performed a qualitative and quantitative analysis of the CST and the hand-related motor fiber tracts (HMFTs). Finally, we have created variability heat maps from 37 subjects for both the aforementioned tracts, which could be utilized as a reference for future studies with clinical focus to explore neuropathology in both trauma and disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.