Evidence map›Paper›PMID 30617730›Full record

ArticleMolecular imaging and biology2019

PET Imaging of HER2-Positive Tumors with Cu-64-Labeled Affibody Molecules.

Shibo Qi, Susan Hoppmann, Yingding Xu, Zhen Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Neuromolecular medicine · 2026
    Article
  3. Review
  4. Druggability of Targets for Diagnostic Radiopharmaceuticals.ACS pharmacology & translational science · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. [Molecules (Basel, Switzerland) · 2021
    Article
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Shibo QiSchool of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin, 300387, China.
Susan HoppmannMolecular Imaging Program at Stanford (MIPS), Department of Radiology, and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, 94305-5344, USA.
Yingding XuMolecular Imaging Program at Stanford (MIPS), Department of Radiology, and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, 94305-5344, USA.
Zhen ChengMolecular Imaging Program at Stanford (MIPS), Department of Radiology, and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, Stanford University, Stanford, CA, 94305-5344, USA. zcheng@stanford.edu.ORCID 0000-0001-8177-9463
Stanford University · USStanford Medicine · USTiangong University · CN

Funding

Radiolabeled RGD Peptides for Breast Cancer Imaging and TherapyR01CA119053 · NCI · STANFORD UNIVERSITY · PI CHENG, ZHEN · 2007 to 2010
$952k
6 · The paper itself

Abstract

purposePrevious studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, Z PROCEDURES: In our study, three anti-HER2 affibody proteins-based PET probes were prepared, and their in vivo performance was evaluated in mice bearing HER2-positive subcutaneous SKOV3 tumors. The affibody analogues, Ac-Cys-Z

resultsCell uptake assays showed high and specific uptake by incubation of Cu-64-labeled affibodies with SKOV3 cells. The affinities (K

conclusionsThe three Cu-64-labeled Z

Indexed as

Positron-Emission TomographyAnimalsCell Line, TumorCopper RadioisotopesFemaleHumansMetabolomicsMice, NudeRecombinant Fusion ProteinsTissue DistributionCopper-64Copper RadioisotopesRecombinant Fusion ProteinsAffibodyCu-64HER2PETTumor

Identifiers

PMID30617730
OpenAlexW2910434309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.