ArticleMikrochimica acta2019
Determination of 17β-estradiol by surface-enhanced Raman spectroscopy merged with hybridization chain reaction amplification on Au@Ag core-shell nanoparticles.
Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- 17β-estradiol biosensors based on different bioreceptors and their applications.Frontiers in bioengineering and biotechnology · 2024Review
- Electrochemical aptasensor based on electrodeposited poly(3,4-ethylenedioxythiophene)-graphene oxide coupled with Au@Pt nanocrystals for the detection of 17β-estradiol.Mikrochimica acta · 2022Article
- An enzyme free fluorescence resonance transfer strategy based on hybrid chain reaction and triplex DNA for Vibrio parahaemolyticus.Scientific reports · 2020Article
- Graphene/aptamer probes for small molecule detection: from in vitro test to in situ imaging.Mikrochimica acta · 2020Review
- Development and Application of Aptamer-Based Surface-Enhanced Raman Spectroscopy Sensors in Quantitative Analysis and Biotherapy.Sensors (Basel, Switzerland) · 2019Review
- Aptamer-based fluorometric determination for mucin 1 using gold nanoparticles and carbon dots.Mikrochimica acta · 2019Article
- Aptamer based ratiometric electrochemical sensing of 17β-estradiol using an electrode modified with gold nanoparticles, thionine, and multiwalled carbon nanotubes.Mikrochimica acta · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
The authors describe an aptamer-based assay for 17β-estradiol. It relies on the combined use of surface enhanced Raman scattering (SERS) and hybridization chain reaction (HCR). The aptamer against 17β-estradiol is applied as the recognition probes, and this results in excellent specificity. Specific recognition of target 17β-estradiol induce the freedom of DNA 2, which will open the stem-loop structure of probe 1 on the Au@Ag and form the partial dsDNA structure. With the nicking enzyme, the partial dsDNA will be hydrolyzed and the reside ssDNA on Au@Ag will form a small stem-loop structure. With the help of the other probe 2 modified Au@Ag and pre-immobilized probe 3 on the well of the microplate, an enzyme-free HCR can occur and tremendous Au@Ag can be assembled along the formed dsDNA in HCR, which can act as the excellent substrate for Raman measurement and greatly amplify the Raman signal of R6G on the Au@Ag. Afterwards, the key factor, ratio between probe 2-Au@Ag (P2) and probe1-Au@Ag (P1), affects the detection sensitivity is systematically optimized for the best sensing performance. The SERS signal of R6G, best measured at 1651 cm
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